PDB: 285 resultsInfo pagesStatus searchChemie searchBIRD

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5K24	Crystal structure of the complex between phosphatase PRL-2 in the oxidized state with the Bateman domain of murine magnesium transporter CNNM3 Descriptor: CITRATE ANION, Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 Authors: Kozlov, G, Gulerez, I, Gehring, K. Deposit date: 2016-05-18 Release date: 2016-10-12 Last modified: 2018-10-03 Method: X-RAY DIFFRACTION (3.1 Å) Cite: PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5K25	Crystal structure of human phosphatase PRL-2 in complex with the ADP-bound Bateman domain of human magnesium transporter CNNM3 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 Authors: Gulerez, I, Kozlov, G, Gehring, K. Deposit date: 2016-05-18 Release date: 2016-10-12 Last modified: 2018-10-03 Method: X-RAY DIFFRACTION (3.05 Å) Cite: PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5K22	Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3 Descriptor: Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 Authors: Kozlov, G, Wu, H, Gehring, K. Deposit date: 2016-05-18 Release date: 2016-10-12 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (3 Å) Cite: Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis. EMBO Rep., 17, 2016
1MEH	Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with IMP and MOA bound Descriptor: INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, INOSINIC ACID, MYCOPHENOLIC ACID, ... Authors: Prosise, G.L, Luecke, H. Deposit date: 2002-08-08 Release date: 2003-08-12 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structures of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with Substrate, Cofactor and Analogs: A Structural Basis for the Random-in Ordered-out Kinetic Mechanism J.Mol.Biol., 326, 2003
1MEI	Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with XMP and mycophenolic acid bound Descriptor: INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, MYCOPHENOLIC ACID, POTASSIUM ION, ... Authors: Prosise, G.L, Luecke, H. Deposit date: 2002-08-08 Release date: 2003-08-12 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structures of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with Substrate, Cofactor and Analogs: A Structural Basis for the Random-in Ordered-out Kinetic Mechanism J.Mol.Biol., 326, 2003
1ME8	Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with RVP bound Descriptor: INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, POTASSIUM ION, RIBAVIRIN MONOPHOSPHATE, ... Authors: Prosise, G.L, Wu, J, Luecke, H. Deposit date: 2002-08-08 Release date: 2003-01-14 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structure of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with the Inhibitor Ribavirin Monophosphate Reveals a Catalysis-dependent Ion-binding Site J.Biol.Chem., 277, 2002
8S5I	Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, basal state, single particle reconstruction Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE Authors: McCorvie, T.J, Yue, W.W. Deposit date: 2024-02-23 Release date: 2024-04-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
8S5L	Full-length human cystathionine beta-synthase, basal state, partially degraded tetramer Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE Authors: McCorvie, T.J, Yue, W.W. Deposit date: 2024-02-23 Release date: 2024-04-17 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
8S5J	Full-length human cystathionine beta-synthase, basal state, helical reconstruction Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE Authors: McCorvie, T.J, Yue, W.W. Deposit date: 2024-02-23 Release date: 2024-04-17 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
8S5K	Full-length human cystathionine beta-synthase, basal state, single particle reconstruction Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE Authors: McCorvie, T.J, Yue, W.W. Deposit date: 2024-02-23 Release date: 2024-04-17 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
8S5H	Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, basal state, helical reconstruction Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE Authors: McCorvie, T.J, Yue, W.W. Deposit date: 2024-02-23 Release date: 2024-04-17 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
8S5M	Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, SAM bound, activated state, helical reconstruction Descriptor: Cystathionine beta-synthase, S-ADENOSYLMETHIONINE Authors: McCorvie, T.J, Yue, W.W. Deposit date: 2024-02-23 Release date: 2024-04-17 Method: ELECTRON MICROSCOPY (4 Å) Cite: Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
8F6D	Crystal structure of the CNNM2 CBS-pair domain in complex with ARL15 Descriptor: ADP-ribosylation factor-like protein 15, Metal transporter CNNM2 Authors: Kozlov, G, Mahbub, L, Gehring, K. Deposit date: 2022-11-16 Release date: 2023-07-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15. Elife, 12, 2023
8FOZ	Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; filament assembly interface reconstruction Descriptor: INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: O'Neill, A.G, Kollman, J.M. Deposit date: 2023-01-03 Release date: 2023-04-19 Last modified: 2023-08-09 Method: ELECTRON MICROSCOPY (2 Å) Cite: Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
8FUZ	Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; filament assembly interface reconstruction Descriptor: INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: O'Neill, A.G, Kollman, J.M. Deposit date: 2023-01-18 Release date: 2023-04-19 Last modified: 2023-08-09 Method: ELECTRON MICROSCOPY (2.1 Å) Cite: Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
6B2E	Structure of full length human AMPK (a2b2g1) in complex with a small molecule activator SC4. Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... Authors: Ngoei, K.R.W, Langendorf, C.G, Ling, N.X.Y, Hoque, A, Johnson, S, Camerino, M.C, Walker, S.R, Bozikis, Y.E, Dite, T.A, Ovens, A.J, Smiles, W.J, Jacobs, R, Huang, H, Parker, M.W, Scott, J.W, Rider, M.H, Kemp, B.E, Foitzik, R.C, Baell, J.B, Oakhill, J.S. Deposit date: 2017-09-19 Release date: 2018-04-25 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4. Cell Chem Biol, 25, 2018
6B1U	Structure of full-length human AMPK (a2b1g1) in complex with a small molecule activator SC4 Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... Authors: Ngoei, K.R.W, Langendorf, C.G, Ling, N.X.Y, Hoque, A, Johnson, S, Camerino, M.C, Walker, S.R, Bozikis, Y.E, Dite, T.A, Ovens, A.J, Smiles, W.J, Jacobs, R, Huang, H, Parker, M.W, Scott, J.W, Rider, M.H, Kemp, B.E, Foitzik, R.C, Baell, J.B, Oakhill, J.S. Deposit date: 2017-09-19 Release date: 2018-04-25 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.77 Å) Cite: Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4. Cell Chem Biol, 25, 2018
8G9B	Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; compressed filament segment reconstruction Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... Authors: O'Neill, A.G, Kollman, J.M. Deposit date: 2023-02-21 Release date: 2023-04-19 Last modified: 2023-08-09 Method: ELECTRON MICROSCOPY (3 Å) Cite: Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
8G8F	Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; extended filament segment reconstruction Descriptor: ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, ... Authors: O'Neill, A.G, Kollman, J.M. Deposit date: 2023-02-17 Release date: 2023-04-19 Last modified: 2023-08-09 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
6C9G	AMP-activated protein kinase bound to pharmacological activator R739 Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... Authors: Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Hitoshi, Y, Brunzelle, J.S, Griffin, P.R, Xu, H.E, Melcher, K. Deposit date: 2018-01-26 Release date: 2018-11-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states. J. Biol. Chem., 294, 2019
6C9F	AMP-activated protein kinase bound to pharmacological activator R734 Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... Authors: Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Hitoshi, Y, Brunzelle, J.S, Griffin, P.R, Xu, H.E, Melcher, K. Deposit date: 2018-01-26 Release date: 2018-11-28 Last modified: 2019-12-25 Method: X-RAY DIFFRACTION (2.924 Å) Cite: Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states. J. Biol. Chem., 294, 2019
6C9J	AMP-activated protein kinase bound to pharmacological activator R734 Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... Authors: Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Brunzelle, J.S, Hitoshi, Y, Griffin, P.R, Xu, H.E, Melcher, K. Deposit date: 2018-01-26 Release date: 2018-11-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states. J. Biol. Chem., 294, 2019
6I0O	Structure of human IMP dehydrogenase, isoform 2, bound to GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase 2, SULFATE ION Authors: Buey, R.M, Fernandez-Justel, D, Revuelta, J.L. Deposit date: 2018-10-26 Release date: 2019-01-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.623 Å) Cite: A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J. Mol. Biol., 431, 2019
6C9H	non-phosphorylated AMP-activated protein kinase bound to pharmacological activator R734 Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... Authors: Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Hitoshi, Y, Brunzelle, J.S, Griffin, P.R, Xu, H.E, Melcher, K. Deposit date: 2018-01-26 Release date: 2018-11-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states. J. Biol. Chem., 294, 2019
6I0M	Structure of human IMP dehydrogenase, isoform 2, bound to GDP Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, Inosine-5'-monophosphate dehydrogenase 2, ... Authors: Buey, R.M, Fernandez-Justel, D, Revuelta, J.L. Deposit date: 2018-10-26 Release date: 2019-01-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.567 Å) Cite: A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J. Mol. Biol., 431, 2019

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