8FUZ
Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; filament assembly interface reconstruction
Summary for 8FUZ
| Entry DOI | 10.2210/pdb8fuz/pdb |
| EMDB information | 29357 29482 |
| Descriptor | Inosine-5'-monophosphate dehydrogenase 2, INOSINIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total) |
| Functional Keywords | filament, dehydrogenase, cbs domain, bateman domain, purine biosynthesis, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 8 |
| Total formula weight | 459808.67 |
| Authors | O'Neill, A.G.,Kollman, J.M. (deposition date: 2023-01-18, release date: 2023-04-19, Last modification date: 2023-08-09) |
| Primary citation | O'Neill, A.G.,Burrell, A.L.,Zech, M.,Elpeleg, O.,Harel, T.,Edvardson, S.,Mor-Shaked, H.,Rippert, A.L.,Nomakuchi, T.,Izumi, K.,Kollman, J.M. Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299:105012-105012, 2023 Cited by PubMed: 37414152DOI: 10.1016/j.jbc.2023.105012 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.1 Å) |
Structure validation
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