8FUZ
Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; filament assembly interface reconstruction
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Inosine-5'-monophosphate dehydrogenase 2 | polymer | 519 | 56464.5 | 8 | UniProt (P12268) Pfam (PF00478) Pfam (PF00571) | Homo sapiens (human) | IMP dehydrogenase 2,IMPD 2,IMPDH 2,Inosine-5'-monophosphate dehydrogenase type II,IMP dehydrogenase II,IMPDH-II |
| 2 | I, K, M, O, Q... (A, B, C, D, E...) | INOSINIC ACID | non-polymer | 348.2 | 8 | Chemie (IMP) | |||
| 3 | J, L, N, P, R... (A, B, C, D, E...) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 8 | Chemie (NAD) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 514 (UniProt: P12268)
| PDB | External Database | Details |
|---|---|---|
| Ser -4 | - | expression tag |
| Glu -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Pro 245 | Leu 245 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 451715.6 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 8093.0 | |
| All* | Total formula weight | 459808.7 |
