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8FUZ

Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; filament assembly interface reconstruction

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003677molecular_functionDNA binding
A0003723molecular_functionRNA binding
A0003824molecular_functioncatalytic activity
A0003938molecular_functionIMP dehydrogenase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005778cellular_componentperoxisomal membrane
A0005829cellular_componentcytosol
A0006164biological_processpurine nucleotide biosynthetic process
A0006177biological_processGMP biosynthetic process
A0006183biological_processGTP biosynthetic process
A0007623biological_processcircadian rhythm
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0034774cellular_componentsecretory granule lumen
A0046651biological_processlymphocyte proliferation
A0046872molecular_functionmetal ion binding
A0070062cellular_componentextracellular exosome
A0071353biological_processcellular response to interleukin-4
A0097294biological_process'de novo' XMP biosynthetic process
A1904813cellular_componentficolin-1-rich granule lumen
B0000166molecular_functionnucleotide binding
B0003677molecular_functionDNA binding
B0003723molecular_functionRNA binding
B0003824molecular_functioncatalytic activity
B0003938molecular_functionIMP dehydrogenase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005778cellular_componentperoxisomal membrane
B0005829cellular_componentcytosol
B0006164biological_processpurine nucleotide biosynthetic process
B0006177biological_processGMP biosynthetic process
B0006183biological_processGTP biosynthetic process
B0007623biological_processcircadian rhythm
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0034774cellular_componentsecretory granule lumen
B0046651biological_processlymphocyte proliferation
B0046872molecular_functionmetal ion binding
B0070062cellular_componentextracellular exosome
B0071353biological_processcellular response to interleukin-4
B0097294biological_process'de novo' XMP biosynthetic process
B1904813cellular_componentficolin-1-rich granule lumen
C0000166molecular_functionnucleotide binding
C0003677molecular_functionDNA binding
C0003723molecular_functionRNA binding
C0003824molecular_functioncatalytic activity
C0003938molecular_functionIMP dehydrogenase activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005778cellular_componentperoxisomal membrane
C0005829cellular_componentcytosol
C0006164biological_processpurine nucleotide biosynthetic process
C0006177biological_processGMP biosynthetic process
C0006183biological_processGTP biosynthetic process
C0007623biological_processcircadian rhythm
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0034774cellular_componentsecretory granule lumen
C0046651biological_processlymphocyte proliferation
C0046872molecular_functionmetal ion binding
C0070062cellular_componentextracellular exosome
C0071353biological_processcellular response to interleukin-4
C0097294biological_process'de novo' XMP biosynthetic process
C1904813cellular_componentficolin-1-rich granule lumen
D0000166molecular_functionnucleotide binding
D0003677molecular_functionDNA binding
D0003723molecular_functionRNA binding
D0003824molecular_functioncatalytic activity
D0003938molecular_functionIMP dehydrogenase activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005778cellular_componentperoxisomal membrane
D0005829cellular_componentcytosol
D0006164biological_processpurine nucleotide biosynthetic process
D0006177biological_processGMP biosynthetic process
D0006183biological_processGTP biosynthetic process
D0007623biological_processcircadian rhythm
D0016020cellular_componentmembrane
D0016491molecular_functionoxidoreductase activity
D0034774cellular_componentsecretory granule lumen
D0046651biological_processlymphocyte proliferation
D0046872molecular_functionmetal ion binding
D0070062cellular_componentextracellular exosome
D0071353biological_processcellular response to interleukin-4
D0097294biological_process'de novo' XMP biosynthetic process
D1904813cellular_componentficolin-1-rich granule lumen
E0000166molecular_functionnucleotide binding
E0003677molecular_functionDNA binding
E0003723molecular_functionRNA binding
E0003824molecular_functioncatalytic activity
E0003938molecular_functionIMP dehydrogenase activity
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005778cellular_componentperoxisomal membrane
E0005829cellular_componentcytosol
E0006164biological_processpurine nucleotide biosynthetic process
E0006177biological_processGMP biosynthetic process
E0006183biological_processGTP biosynthetic process
E0007623biological_processcircadian rhythm
E0016020cellular_componentmembrane
E0016491molecular_functionoxidoreductase activity
E0034774cellular_componentsecretory granule lumen
E0046651biological_processlymphocyte proliferation
E0046872molecular_functionmetal ion binding
E0070062cellular_componentextracellular exosome
E0071353biological_processcellular response to interleukin-4
E0097294biological_process'de novo' XMP biosynthetic process
E1904813cellular_componentficolin-1-rich granule lumen
F0000166molecular_functionnucleotide binding
F0003677molecular_functionDNA binding
F0003723molecular_functionRNA binding
F0003824molecular_functioncatalytic activity
F0003938molecular_functionIMP dehydrogenase activity
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005778cellular_componentperoxisomal membrane
F0005829cellular_componentcytosol
F0006164biological_processpurine nucleotide biosynthetic process
F0006177biological_processGMP biosynthetic process
F0006183biological_processGTP biosynthetic process
F0007623biological_processcircadian rhythm
F0016020cellular_componentmembrane
F0016491molecular_functionoxidoreductase activity
F0034774cellular_componentsecretory granule lumen
F0046651biological_processlymphocyte proliferation
F0046872molecular_functionmetal ion binding
F0070062cellular_componentextracellular exosome
F0071353biological_processcellular response to interleukin-4
F0097294biological_process'de novo' XMP biosynthetic process
F1904813cellular_componentficolin-1-rich granule lumen
G0000166molecular_functionnucleotide binding
G0003677molecular_functionDNA binding
G0003723molecular_functionRNA binding
G0003824molecular_functioncatalytic activity
G0003938molecular_functionIMP dehydrogenase activity
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005778cellular_componentperoxisomal membrane
G0005829cellular_componentcytosol
G0006164biological_processpurine nucleotide biosynthetic process
G0006177biological_processGMP biosynthetic process
G0006183biological_processGTP biosynthetic process
G0007623biological_processcircadian rhythm
G0016020cellular_componentmembrane
G0016491molecular_functionoxidoreductase activity
G0034774cellular_componentsecretory granule lumen
G0046651biological_processlymphocyte proliferation
G0046872molecular_functionmetal ion binding
G0070062cellular_componentextracellular exosome
G0071353biological_processcellular response to interleukin-4
G0097294biological_process'de novo' XMP biosynthetic process
G1904813cellular_componentficolin-1-rich granule lumen
H0000166molecular_functionnucleotide binding
H0003677molecular_functionDNA binding
H0003723molecular_functionRNA binding
H0003824molecular_functioncatalytic activity
H0003938molecular_functionIMP dehydrogenase activity
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005778cellular_componentperoxisomal membrane
H0005829cellular_componentcytosol
H0006164biological_processpurine nucleotide biosynthetic process
H0006177biological_processGMP biosynthetic process
H0006183biological_processGTP biosynthetic process
H0007623biological_processcircadian rhythm
H0016020cellular_componentmembrane
H0016491molecular_functionoxidoreductase activity
H0034774cellular_componentsecretory granule lumen
H0046651biological_processlymphocyte proliferation
H0046872molecular_functionmetal ion binding
H0070062cellular_componentextracellular exosome
H0071353biological_processcellular response to interleukin-4
H0097294biological_process'de novo' XMP biosynthetic process
H1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PROSITE/UniProt
site_idPS00487
Number of Residues13
DetailsIMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRVGMGsGSICiT
ChainResidueDetails
ALEU321-THR333

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsACT_SITE: Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:10097070
ChainResidueDetails
ACYS331
BCYS331
CCYS331
DCYS331
ECYS331
FCYS331
GCYS331
HCYS331

site_idSWS_FT_FI2
Number of Residues8
DetailsACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03156
ChainResidueDetails
AARG429
BARG429
CARG429
DARG429
EARG429
FARG429
GARG429
HARG429

site_idSWS_FT_FI3
Number of Residues24
DetailsBINDING:
ChainResidueDetails
AASP274
DASP274
DASP364
DGLY387
EASP274
EASP364
EGLY387
FASP274
FASP364
FGLY387
GASP274
AASP364
GASP364
GGLY387
HASP274
HASP364
HGLY387
AGLY387
BASP274
BASP364
BGLY387
CASP274
CASP364
CGLY387

site_idSWS_FT_FI4
Number of Residues56
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03156
ChainResidueDetails
AGLY324
BTYR411
BGLN441
BGLU500
BGLY501
BGLY502
CGLY324
CSER329
CTYR411
CGLN441
CGLU500
ASER329
CGLY501
CGLY502
DGLY324
DSER329
DTYR411
DGLN441
DGLU500
DGLY501
DGLY502
EGLY324
ATYR411
ESER329
ETYR411
EGLN441
EGLU500
EGLY501
EGLY502
FGLY324
FSER329
FTYR411
FGLN441
AGLN441
FGLU500
FGLY501
FGLY502
GGLY324
GSER329
GTYR411
GGLN441
GGLU500
GGLY501
GGLY502
AGLU500
HGLY324
HSER329
HTYR411
HGLN441
HGLU500
HGLY501
HGLY502
AGLY501
AGLY502
BGLY324
BSER329

site_idSWS_FT_FI5
Number of Residues24
DetailsBINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|Ref.28
ChainResidueDetails
AGLY326
DGLY326
DGLY328
DCYS331
EGLY326
EGLY328
ECYS331
FGLY326
FGLY328
FCYS331
GGLY326
AGLY328
GGLY328
GCYS331
HGLY326
HGLY328
HCYS331
ACYS331
BGLY326
BGLY328
BCYS331
CGLY326
CGLY328
CCYS331

site_idSWS_FT_FI6
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER122
BSER122
CSER122
DSER122
ESER122
FSER122
GSER122
HSER122

site_idSWS_FT_FI7
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER160
BSER160
CSER160
DSER160
ESER160
FSER160
GSER160
HSER160

site_idSWS_FT_FI8
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR400
BTYR400
CTYR400
DTYR400
ETYR400
FTYR400
GTYR400
HTYR400

site_idSWS_FT_FI9
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER416
BSER416
CSER416
DSER416
ESER416
FSER416
GSER416
HSER416

site_idSWS_FT_FI10
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS511
BLYS511
CLYS511
DLYS511
ELYS511
FLYS511
GLYS511
HLYS511

site_idSWS_FT_FI11
Number of Residues32
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS195
CLYS208
CLYS438
DLYS195
DLYS208
DLYS438
ELYS195
ELYS208
ELYS438
FLYS195
FLYS208
FLYS438
GLYS195
GLYS208
GLYS438
HLYS195
ALYS208
HLYS208
HLYS438
ALYS438
BLYS195
BLYS208
BLYS438
CLYS195

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PDB entries from 2024-11-06

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