8G8F
Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; extended filament segment reconstruction
Summary for 8G8F
Entry DOI | 10.2210/pdb8g8f/pdb |
EMDB information | 29357 29482 29848 |
Descriptor | Inosine-5'-monophosphate dehydrogenase 2, ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... (4 entities in total) |
Functional Keywords | filament, dehydrogenase, cbs domain, bateman domain, purine biosynthesis, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 8 |
Total formula weight | 467923.57 |
Authors | O'Neill, A.G.,Kollman, J.M. (deposition date: 2023-02-17, release date: 2023-04-19, Last modification date: 2023-08-09) |
Primary citation | O'Neill, A.G.,Burrell, A.L.,Zech, M.,Elpeleg, O.,Harel, T.,Edvardson, S.,Mor-Shaked, H.,Rippert, A.L.,Nomakuchi, T.,Izumi, K.,Kollman, J.M. Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299:105012-105012, 2023 Cited by PubMed: 37414152DOI: 10.1016/j.jbc.2023.105012 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.6 Å) |
Structure validation
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