8G8F
Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; extended filament segment reconstruction
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Inosine-5'-monophosphate dehydrogenase 2 | polymer | 519 | 56464.5 | 8 | UniProt (P12268) Pfam (PF00478) Pfam (PF00571) In PDB | Homo sapiens (human) | IMP dehydrogenase 2,IMPD 2,IMPDH 2,Inosine-5'-monophosphate dehydrogenase type II,IMP dehydrogenase II,IMPDH-II |
2 | F, G, A, H, B... | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 16 | Chemie (ATP) | |||
3 | E, F, G, A, H... | INOSINIC ACID | non-polymer | 348.2 | 8 | Chemie (IMP) | |||
4 | E, F, G, A, H... | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 8 | Chemie (NAD) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 514 (UniProt: P12268)
PDB | External Database | Details |
---|---|---|
Ser -4 | - | expression tag |
Glu -3 | - | expression tag |
Phe -2 | - | expression tag |
Glu -1 | - | expression tag |
Leu 0 | - | expression tag |
Pro 245 | Leu 245 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 451715.6 | |
Non-Polymers* | Number of molecules | 32 |
Total formula weight | 16207.9 | |
All* | Total formula weight | 467923.6 |