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8X85	Structure of leptin-LepR dimer Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor, ... Authors: Xie, Y.F, Shang, G.J, Qi, J.X, Gao, G.F. Deposit date: 2023-11-27 Release date: 2024-08-07 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Structural plasticity of human leptin binding to its receptor LepR Hlife, 1, 2023
8X80	Structure of leptin-LepR trimer with a small gap Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, ... Authors: Xie, Y.F, Gao, G.F. Deposit date: 2023-11-27 Release date: 2024-08-07 Method: ELECTRON MICROSCOPY (3.88 Å) Cite: Structural plasticity of human leptin binding to its receptor LepR Hlife, 1, 2023
7K7J	EphB6 receptor ectodomain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-B receptor 6 Authors: Goldgur, Y, Himanen, J. Deposit date: 2020-09-22 Release date: 2021-04-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.004 Å) Cite: Structure of the EphB6 receptor ectodomain. Plos One, 16, 2021
3UP1	Crystal structure of the unliganded human interleukin-7 receptor extracellular domain Descriptor: 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... Authors: McElroy, C.A, Holland, P.J, Walsh, S.T.R. Deposit date: 2011-11-17 Release date: 2012-02-08 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural reorganization of the interleukin-7 signaling complex. Proc.Natl.Acad.Sci.USA, 109, 2012
3UTO	Twitchin kinase region from C.elegans (Fn31-NL-kin-CRD-Ig26) Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... Authors: Castelmur, E, Barbieri, S, Mayans, O. Deposit date: 2011-11-26 Release date: 2012-08-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase. Proc.Natl.Acad.Sci.USA, 109, 2012
3FL7	Crystal structure of the human ephrin A2 ectodomain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Ephrin receptor, ... Authors: Walker, J.R, Yermekbayeva, L, Seitova, A, Butler-Cole, C, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) Deposit date: 2008-12-18 Release date: 2009-01-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Architecture of Eph receptor clusters. Proc.Natl.Acad.Sci.USA, 107, 2010
7STI	Full-length insulin receptor bound with unsaturated insulin WT (1 insulin bound) asymmetric conformation Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-13 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STJ	Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 1) Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-14 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STK	Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 2) Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-14 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STH	Full-length insulin receptor bound with unsaturated insulin WT (2 insulin bound) symmetric conformation Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-13 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
8GUY	human insulin receptor bound with two insulin molecules Descriptor: Insulin A chain, Insulin, isoform 2, ... Authors: Kim, J, Yunn, N, Ryu, S, Cho, Y. Deposit date: 2022-09-14 Release date: 2022-11-09 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (4.18 Å) Cite: Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
8G4L	Cryo-EM structure of the human cardiac myosin filament Descriptor: Myosin light chain 3, Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, ... Authors: Dutta, D, Nguyen, V, Padron, R, Craig, R. Deposit date: 2023-02-10 Release date: 2023-11-01 Last modified: 2023-12-06 Method: ELECTRON MICROSCOPY (6.4 Å) Cite: Cryo-EM structure of the human cardiac myosin filament. Nature, 623, 2023
8FN8	Crystal structure of the C-terminal Fg domain of TNC with the single FN domain of PTPRZ Descriptor: CALCIUM ION, Receptor-type tyrosine-protein phosphatase zeta, Tenascin Authors: Bouyain, S. Deposit date: 2022-12-27 Release date: 2023-07-12 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Protein-protein interactions between tenascin-R and RPTP zeta /phosphacan are critical to maintain the architecture of perineuronal nets. J.Biol.Chem., 299, 2023
8FN9	Crystal structure of the C-terminal Fg domain of TNR with the single FN domain of PTPRZ Descriptor: CALCIUM ION, Receptor-type tyrosine-protein phosphatase zeta, Tenascin-R Authors: Bouyain, S. Deposit date: 2022-12-27 Release date: 2023-07-12 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Protein-protein interactions between tenascin-R and RPTP zeta /phosphacan are critical to maintain the architecture of perineuronal nets. J.Biol.Chem., 299, 2023
3DI2	Crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain Descriptor: Interleukin-7, Interleukin-7 receptor subunit alpha, PENTAETHYLENE GLYCOL Authors: McElroy, C.A, Dohm, J.A, Walsh, S.T.R. Deposit date: 2008-06-19 Release date: 2009-01-27 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural and Biophysical Studies of the Human IL-7/IL-7Ralpha Complex. Structure, 17, 2009
6BRB	Novel non-antibody protein scaffold targeting CD40L Descriptor: CD40 ligand, Tn3-like, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Oganesyan, V, Baca, M, Thisted, T, Grinberg, L, Wu, H, Dall'Acqua, W.F. Deposit date: 2017-11-30 Release date: 2018-12-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.82 Å) Cite: A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity. Sci Transl Med, 11, 2019
3D1M	Crystal Structure of Sonic Hedgehog Bound to the third FNIII domain of CDO Descriptor: CALCIUM ION, Cell adhesion molecule, Sonic hedgehog protein, ... Authors: McLellan, J.S, Leahy, D.J. Deposit date: 2008-05-06 Release date: 2008-09-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature, 455, 2008
3DI3	Crystal structure of the complex of human interleukin-7 with glycosylated human interleukin-7 receptor alpha ectodomain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-7, Interleukin-7 receptor subunit alpha Authors: McElroy, C.A, Dohm, J.A, Walsh, S.T.R. Deposit date: 2008-06-19 Release date: 2009-01-27 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural and Biophysical Studies of the Human IL-7/IL-7Ralpha Complex. Structure, 17, 2009
6CE9	Insulin Receptor ectodomain in complex with two insulin molecules Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. Deposit date: 2018-02-11 Release date: 2018-03-14 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
3HHR	HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX Descriptor: HUMAN GROWTH HORMONE, HUMAN GROWTH HORMONE RECEPTOR (hGHbp) Authors: De Vos, A.M, Ultsch, M, Kossiakoff, A.A. Deposit date: 1993-12-30 Release date: 1994-04-30 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science, 255, 1992
3F7P	Crystal structure of a complex between integrin beta4 and plectin Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... Authors: de Pereda, J.M. Deposit date: 2008-11-10 Release date: 2009-03-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomes Embo J., 28, 2009
6CEB	Insulin Receptor ectodomain in complex with two insulin molecules - C1 symmetry Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. Deposit date: 2018-02-11 Release date: 2018-03-14 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
6CE7	Insulin Receptor ectodomain in complex with one insulin molecule Descriptor: Insulin A chain, Insulin B chain, Insulin receptor, ... Authors: Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. Deposit date: 2018-02-11 Release date: 2018-03-14 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (7.4 Å) Cite: Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
3E0G	Structure of the Leukemia Inhibitory Factor Receptor (LIF-R) domains D1-D5 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Leukemia inhibitory factor receptor, ... Authors: Lupardus, P.J, Garcia, K.C. Deposit date: 2008-07-31 Release date: 2008-09-23 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol.Cell, 31, 2008
5I99	Crystal structure of mouse CNTN3 Ig5-Fn2 domains Descriptor: Contactin-3, GLYCEROL Authors: Nikolaienko, R.M, Bouyain, S. Deposit date: 2016-02-19 Release date: 2016-08-31 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues. J.Biol.Chem., 291, 2016

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