8X80

Structure of leptin-LepR trimer with a small gap

Summary for 8X80

• Entry DOI: 10.2210/pdb8x80/pdb
• EMDB information: 38131
• Descriptor: Leptin receptor, Leptin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: cytokine receptor, hexamer, cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 345962.10

Authors

Xie, Y.F.,Gao, G.F. (deposition date: 2023-11-27, release date: 2024-08-07, Last modification date: 2025-07-02)

• Primary citation: Xie, Y.F.,Li, X.,Qi, J.,Shang, G.,Lu, D.,Gao, G.F.; Structural plasticity of human leptin binding to its receptor LepR; Hlife, 1:115-123, 2023; DOI: 10.1016/j.hlife.2023.10.010

Experimental method

ELECTRON MICROSCOPY (3.88 Å)