8X80

Structure of leptin-LepR trimer with a small gap

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E (A, B, C)	Leptin receptor	polymer	829	94933.6	3	UniProt (P48357) Pfam (PF18589) Pfam (PF00041) Pfam (PF06328)	Homo sapiens (human)	LEP-R,HuB219,OB receptor,OB-R
2	C, D, F (E, D, F)	Leptin	polymer	167	18656.5	3	UniProt (P41159) Pfam (PF02024)	Homo sapiens (human)
3	G (G)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	1	In PDB GlyTouCan (G32152BH)
4	H, I (H, I)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	2	In PDB GlyTouCan (G21290RB)
5	J, K, L, M, N... (A, B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	15	Chemie (NAG)

Sequence modifications

A, B, C: 21 - 839 (UniProt: P48357)

PDB	External Database	Details
Gly 840	-	expression tag
Thr 841	-	expression tag
His 842	-	expression tag
His 843	-	expression tag
His 844	-	expression tag
His 845	-	expression tag
His 846	-	expression tag
His 847	-	expression tag
His 848	-	expression tag
His 849	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	340770.2
Branched	Number of molecules	3
	Total formula weight	1873.8
Non-Polymers*	Number of molecules	15
	Total formula weight	3318.1
All*	Total formula weight	345962.1

*Water molecules are not included.