8X85

Structure of leptin-LepR dimer

Summary for 8X85

Entry DOI	10.2210/pdb8x85/pdb
EMDB information	38136
Descriptor	Leptin receptor, Leptin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	cytokine receptor, tetramer, cytokine
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	230713.46
Authors	Xie, Y.F.,Shang, G.J.,Qi, J.X.,Gao, G.F. (deposition date: 2023-11-27, release date: 2024-08-07, Last modification date: 2025-07-02)
Primary citation	Xie, Y.F.,Li, X.,Qi, J.,Shang, G.,Lu, D.,Gao, G.F. Structural plasticity of human leptin binding to its receptor LepR Hlife, 1:115-123, 2023 Cited by DOI: 10.1016/j.hlife.2023.10.010 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.58 Å)

Structure validation