8X85
Structure of leptin-LepR dimer
Functional Information from PROSITE/UniProt
| site_id | PS01353 |
| Number of Residues | 57 |
| Details | HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NsigaSvanfnltfswpmskvnivqslsayplnsscvi...VsWilsPsdyklmy..Fi.IeW |
| Chain | Residue | Details |
| A | ASN718-TRP774 |
| site_id | PS01355 |
| Number of Residues | 31 |
| Details | HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. IlpgssyevqVRgkrldgpgi...........WSdWStprvF |
| Chain | Residue | Details |
| A | ILE298-PHE328 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1634 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE22-ASP839 | |
| B | PHE22-ASP839 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 30 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:9786864 |
| Chain | Residue | Details |
| A | ASN23 | |
| A | ASN624 | |
| A | ASN659 | |
| A | ASN688 | |
| A | ASN697 | |
| A | ASN728 | |
| A | ASN750 | |
| B | ASN23 | |
| B | ASN41 | |
| B | ASN56 | |
| B | ASN73 | |
| A | ASN41 | |
| B | ASN81 | |
| B | ASN98 | |
| B | ASN187 | |
| B | ASN206 | |
| B | ASN347 | |
| B | ASN624 | |
| B | ASN659 | |
| B | ASN688 | |
| B | ASN697 | |
| B | ASN728 | |
| A | ASN56 | |
| B | ASN750 | |
| A | ASN73 | |
| A | ASN81 | |
| A | ASN98 | |
| A | ASN187 | |
| A | ASN206 | |
| A | ASN347 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:9786864 |
| Chain | Residue | Details |
| A | ASN276 | |
| B | ASN276 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:9786864 |
| Chain | Residue | Details |
| A | ASN397 | |
| B | ASN397 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:9786864 |
| Chain | Residue | Details |
| A | ASN516 | |
| B | ASN516 |
