8X85

Structure of leptin-LepR dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Leptin receptor	polymer	829	94933.6	2	UniProt (P48357) Pfam (PF18589) Pfam (PF00041) Pfam (PF06328)	Homo sapiens (human)	LEP-R,HuB219,OB receptor,OB-R
2	C, D (C, D)	Leptin	polymer	167	18656.5	2	UniProt (P41159) Pfam (PF02024)	Homo sapiens (human)
3	E (E)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	1	In PDB GlyTouCan (G32152BH)
4	F (F)	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	1	In PDB GlyTouCan (G86851RC)
5	G, H, I, J, K... (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	11	Chemie (NAG)

Sequence modifications

A, B: 21 - 839 (UniProt: P48357)

PDB	External Database	Details
Gly 840	-	expression tag
Thr 841	-	expression tag
His 842	-	expression tag
His 843	-	expression tag
His 844	-	expression tag
His 845	-	expression tag
His 846	-	expression tag
His 847	-	expression tag
His 848	-	expression tag
His 849	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	227180.1
Branched	Number of molecules	2
	Total formula weight	1100.0
Non-Polymers*	Number of molecules	11
	Total formula weight	2433.3
All*	Total formula weight	230713.5

*Water molecules are not included.