5SXT
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5UEY
| BRD4_BD2_A-1412838 | Descriptor: | 5-[2-(2,4-difluorophenoxy)-5-{[ethyl(dihydroxy)-lambda~4~-sulfanyl]amino}phenyl]-4-ethoxy-1-methylpyridin-2(1H)-one, Bromodomain-containing protein 4 | Authors: | Park, C.H. | Deposit date: | 2017-01-03 | Release date: | 2017-05-10 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors. J. Med. Chem., 60, 2017
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5VBX
| Crystal structure of holo-[acyl-carrier-protein] synthase (AcpS) from Escherichia coli | Descriptor: | 1,2-ETHANEDIOL, Holo-[acyl-carrier-protein] synthase, SODIUM ION | Authors: | Marcella, A.M, Barb, A.W. | Deposit date: | 2017-03-30 | Release date: | 2017-11-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure, High Affinity, and Negative Cooperativity of the Escherichia coli Holo-(Acyl Carrier Protein):Holo-(Acyl Carrier Protein) Synthase Complex. J. Mol. Biol., 429, 2017
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5V8Z
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5UVD
| Crystal structure of an antigenic nucleotidyltransferase-like protein from Paracoccidioides brasiliensis | Descriptor: | MAGNESIUM ION, Nucleotidyltransferase-like protein | Authors: | Nagem, R.A.P, Costa, M.A.F, Rodrigues, F.T.G, Coitinho, J.B.C. | Deposit date: | 2017-02-20 | Release date: | 2018-01-31 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural and immunological characterization of a new nucleotidyltransferase-like antigen from Paracoccidioides brasiliensis. Mol.Immunol., 112, 2019
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5UP5
| Solution structure of the de novo mini protein EHEE_rd1_0284 | Descriptor: | EHEE_rd1_0284 | Authors: | Houliston, S, Rocklin, G.J, Lemak, A, Carter, L, Chidyausiku, T.M, Baker, D, Arrowsmith, C.H. | Deposit date: | 2017-02-01 | Release date: | 2017-07-26 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Global analysis of protein folding using massively parallel design, synthesis, and testing. Science, 357, 2017
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5V3I
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5V90
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5VA9
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5T7L
| Pt(II)-mediated copper-dependent interactions between ATOX1 and MNK1 | Descriptor: | COPPER (II) ION, Copper transport protein ATOX1, Copper-transporting ATPase 1, ... | Authors: | Caliandro, R, Mirabelli, V, Caliandro, R, Rosato, A, Lasorsa, A, Galliani, A, Arnesano, F, Natile, G. | Deposit date: | 2016-09-05 | Release date: | 2016-10-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Mechanistic and Structural Basis for Inhibition of Copper Trafficking by Platinum Anticancer Drugs. J.Am.Chem.Soc., 141, 2019
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5T7Q
| TIRAP phosphoinositide-binding motif | Descriptor: | Toll/interleukin-1 receptor domain-containing adapter protein | Authors: | Capelluto, D.G.S, Ellena, J.F, Armstrong, G, Zhao, X, Xiao, S. | Deposit date: | 2016-09-05 | Release date: | 2017-03-08 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif. Sci Rep, 7, 2017
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5T0R
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5T0S
| Synaptotagmin 1 C2B domain, cadmium-bound | Descriptor: | CADMIUM ION, SODIUM ION, Synaptotagmin-1 | Authors: | Taylor, A.B, Hart, P.J, Igumenova, T.I. | Deposit date: | 2016-08-16 | Release date: | 2017-06-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions. Biochemistry, 56, 2017
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5T2Z
| Crystal Structure of Multi-drug Resistant HIV-1 Protease PR-S17 in Complex with Darunavir | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease | Authors: | Agniswamy, J, Weber, I.T. | Deposit date: | 2016-08-24 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics. PLoS ONE, 11, 2016
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5UEW
| BRD2 Bromodomain2 with A-1360579 | Descriptor: | Bromodomain-containing protein 2, N-[3-(4-methoxy-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-4-phenoxyphenyl]methanesulfonamide | Authors: | Park, C.H. | Deposit date: | 2017-01-03 | Release date: | 2017-05-10 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors. J. Med. Chem., 60, 2017
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5TWI
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5TXJ
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5UI0
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5TPB
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5VR4
| RNA octamer containing 2'-F-4'-OMe U. | Descriptor: | COBALT TETRAAMMINE ION, RNA (5'-R(*CP*GP*AP*AP*(UMO)P*UP*CP*G)-3') | Authors: | Harp, J.M, Egli, M. | Deposit date: | 2017-05-10 | Release date: | 2017-10-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | 4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing. J. Am. Chem. Soc., 139, 2017
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5VL6
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5VFF
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5UJL
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5UJN
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5V2B
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