5TPB

Binding domain of BoNT/A complexed with ganglioside variant

Summary for 5TPB

• Entry DOI: 10.2210/pdb5tpb/pdb
• Related: 2VU9
• Descriptor: Botulinum neurotoxin type A, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose, N-acetyl-alpha-neuraminic acid, ... (4 entities in total)
• Functional Keywords: binding domain, lectin, ganglioside binding, hydrolase
• Biological source: Clostridium botulinum
• Cellular location: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: P10845
• Total number of polymer chains: 2
• Total formula weight: 104119.42

Authors

Berntsson, R.P.-A.,Svensson, L.M.,Stenmark, P. (deposition date: 2016-10-20, release date: 2017-01-18, Last modification date: 2020-07-29)

• Primary citation: Hamark, C.,Berntsson, R.P.,Masuyer, G.,Henriksson, L.M.,Gustafsson, R.,Stenmark, P.,Widmalm, G.; Glycans Confer Specificity to the Recognition of Ganglioside Receptors by Botulinum Neurotoxin A.; J. Am. Chem. Soc., 139:218-230, 2017; PubMed: 27958736; DOI: 10.1021/jacs.6b09534

Experimental method

X-RAY DIFFRACTION (2.6 Å)