5T7L

Pt(II)-mediated copper-dependent interactions between ATOX1 and MNK1

Summary for 5T7L

Entry DOI	10.2210/pdb5t7l/pdb
Descriptor	Copper transport protein ATOX1, Copper-transporting ATPase 1, PLATINUM (II) ION, ... (5 entities in total)
Functional Keywords	atox1-mnk1, pt-binding, heterodimer, transport protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	16229.30
Authors	Caliandro, R.,Mirabelli, V.,Caliandro, R.,Rosato, A.,Lasorsa, A.,Galliani, A.,Arnesano, F.,Natile, G. (deposition date: 2016-09-05, release date: 2016-10-12, Last modification date: 2024-01-17)
Primary citation	Lasorsa, A.,Nardella, M.I.,Rosato, A.,Mirabelli, V.,Caliandro, R.,Caliandro, R.,Natile, G.,Arnesano, F. Mechanistic and Structural Basis for Inhibition of Copper Trafficking by Platinum Anticancer Drugs. J.Am.Chem.Soc., 141:12109-12120, 2019 Cited by PubMed: 31283225 DOI: 10.1021/jacs.9b05550 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.83 Å)

Structure validation