5VA9

Human pancreatic alpha amylase in complex with peptide inhibitor piHA-L5(d10Y)

Summary for 5VA9

Entry DOI	10.2210/pdb5va9/pdb
Related	4W93 4X9Y 5E0F 5KEZ
Descriptor	Pancreatic alpha-amylase, Peptide Inhibitor piHA-L5(d10Y), CHLORIDE ION, ... (5 entities in total)
Functional Keywords	amylase, diabetes, obesity, glucosyl hydrolase, peptide inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	116336.44
Authors	Caner, S.,Brayer, G.D. (deposition date: 2017-03-24, release date: 2018-03-28, Last modification date: 2023-10-04)
Primary citation	Goldbach, L.,Vermeulen, B.J.A.,Caner, S.,Liu, M.,Tysoe, C.,van Gijzel, L.,Yoshisada, R.,Trellet, M.,van Ingen, H.,Brayer, G.D.,Bonvin, A.M.J.J.,Jongkees, S.A.K. Folding Then Binding vs Folding Through Binding in Macrocyclic Peptide Inhibitors of Human Pancreatic alpha-Amylase. Acs Chem.Biol., 14:1751-1759, 2019 Cited by PubMed: 31241898 DOI: 10.1021/acschembio.9b00290 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation