5T2Z

Crystal Structure of Multi-drug Resistant HIV-1 Protease PR-S17 in Complex with Darunavir

Summary for 5T2Z

• Entry DOI: 10.2210/pdb5t2z/pdb
• Related: 5T2E
• Descriptor: Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
• Functional Keywords: protease, hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22130.85

Authors

Agniswamy, J.,Weber, I.T. (deposition date: 2016-08-24, release date: 2017-01-11, Last modification date: 2023-10-04)

• Primary citation: Agniswamy, J.,Louis, J.M.,Roche, J.,Harrison, R.W.,Weber, I.T.; Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics.; PLoS ONE, 11:e0168616-e0168616, 2016; PubMed: 27992544; DOI: 10.1371/journal.pone.0168616

Experimental method

X-RAY DIFFRACTION (1.5 Å)