5T2Z
Crystal Structure of Multi-drug Resistant HIV-1 Protease PR-S17 in Complex with Darunavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protease | polymer | 99 | 10791.6 | 2 | UniProt (I7BFC3) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | C (B) | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: I7BFC3)
| PDB | External Database | Details |
|---|---|---|
| Leu 46 | Met 46 | engineered mutation |
| Val 48 | Gly 48 | engineered mutation |
| Ala 67 | Cys 67 | engineered mutation |
| Ile 77 | Val 77 | engineered mutation |
| Ser 82 | Ala 82 | engineered mutation |
| Leu 93 | Ile 93 | engineered mutation |
| Ala 95 | Cys 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21583.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 547.7 | |
| All* | Total formula weight | 22130.9 |
