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2BIK
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Human Pim1 phosphorylated on Ser261
Descriptor: 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, CHLORIDE ION, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1
Authors:Knapp, S, Debreczeni, J, Bullock, A, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Guo, K.
Deposit date:2005-01-22
Release date:2005-02-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human Pim1 Phosphorylated on Ser261
To be Published
2BRB
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Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity
Descriptor: 2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL, SERINE/THREONINE-PROTEIN KINASE CHK1, SULFATE ION
Authors:Foloppe, N, Fisher, L.M, Howes, R, Kierstan, P, Potter, A, Robertson, A.G.S, Surgenor, A.E.
Deposit date:2005-05-04
Release date:2005-05-12
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Based Design of Novel Chk1 Inhibitors: Insights Into Hydrogen Bonding and Protein-Ligand Affinity.
J.Med.Chem., 48, 2005
2C30
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Crystal Structure Of The Human P21-Activated Kinase 6
Descriptor: CHLORIDE ION, PHOSPHATE ION, SERINE/THREONINE-PROTEIN KINASE PAK 6
Authors:Filippakopoulos, P, Berridge, G, Bray, J, Burgess, N, Colebrook, S, Das, S, Eswaran, J, Gileadi, O, Papagrigoriou, E, Savitsky, P, Smee, C, Turnbull, A, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, von Delft, F, Knapp, S.
Deposit date:2005-10-02
Release date:2006-02-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
Structure, 15, 2007
2C6I
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Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor
Descriptor: 4-{[5-(CYCLOHEXYLMETHOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2
Authors:Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E.
Deposit date:2005-11-10
Release date:2005-12-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar.
Bioorg.Med.Chem.Lett., 16, 2006
2BZH
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BU of 2bzh by Molmil
CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, ...
Authors:Debreczeni, J.E, Bullock, A, Knapp, S, von Delft, F, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A.
Deposit date:2005-08-18
Release date:2005-12-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Human Pim1 in Complex with Ruthenium Organometallic Ligands
To be Published
2C3J
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Identification of a buried pocket for potent and selective inhibition of Chk1: prediction and verification
Descriptor: DEBROMOHYMENIALDISINE, SERINE/THREONINE-PROTEIN KINASE CHK1, SULFITE ION
Authors:Foloppe, N, Fisher, L.M, Francis, G, Howes, R, Kierstan, P, Potter, A.
Deposit date:2005-10-10
Release date:2005-11-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification of a Buried Pocket for Potent and Selective Inhibition of Chk1: Prediction and Verification.
Bioorg.Med.Chem., 14, 2006
2BVA
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BU of 2bva by Molmil
Crystal structure of the human P21-activated kinase 4
Descriptor: P21-ACTIVATED KINASE 4
Authors:Debreczeni, J.E, Bunkoczi, G, Eswaran, J, Filippakopoulos, P, Das, S, Fedorov, O, Sundstrom, M, Arrowsmith, C, Edwards, A, von Delft, F, Knapp, S.
Deposit date:2005-06-23
Release date:2005-07-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
Structure, 15, 2007
2CPK
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BU of 2cpk by Molmil
CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CYCLIC ADENOSINE MONOPHOSPHATE-DEPENDENT PROTEIN KINASE
Descriptor: PEPTIDE INHIBITOR 20-MER, cAMP-DEPENDENT PROTEIN KINASE, CATALYTIC SUBUNIT
Authors:Knighton, D.R, Zheng, J, Teneyck, L.F, Ashford, V.A, Xuong, N.-H, Taylor, S.S, Sowadski, J.M.
Deposit date:1992-10-21
Release date:1993-01-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.
Science, 253, 1991
2C6M
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Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor
Descriptor: 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2
Authors:Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E.
Deposit date:2005-11-10
Release date:2005-12-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar.
Bioorg.Med.Chem.Lett., 16, 2006
2CDZ
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4 IN COMPLEX WITH CGP74514A
Descriptor: CHLORIDE ION, N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE, SERINE/THREONINE-PROTEIN KINASE PAK 4, ...
Authors:Debreczeni, J.E, Ugochukwu, E, Eswaran, J, Filippakopoulos, P, Das, S, Fedorov, O, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, von Delft, F, Knapp, S.
Deposit date:2006-01-31
Release date:2006-02-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
Structure, 15, 2007
2B9H
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BU of 2b9h by Molmil
Crystal structure of Fus3 with a docking motif from Ste7
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3, ...
Authors:Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:2005-10-11
Release date:2006-01-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
Mol.Cell, 20, 2005
2BDW
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BU of 2bdw by Molmil
Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II
Descriptor: Hypothetical protein K11E8.1d
Authors:Rosenberg, O.S, Kuriyan, J.
Deposit date:2005-10-20
Release date:2005-12-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme
Cell(Cambridge,Mass.), 123, 2005
2DUV
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BU of 2duv by Molmil
Structure of CDK2 with a 3-hydroxychromones
Descriptor: 2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONE, Cell division protein kinase 2
Authors:Kim, K.H, Lee, J, Park, T, Jeong, S, Hong, C.
Deposit date:2006-07-27
Release date:2007-01-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.
Bioorg.Med.Chem.Lett., 17, 2007
2DWB
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Aurora-A kinase complexed with AMPPNP
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, Serine/threonine-protein kinase 6
Authors:Kukimoto-Niino, M, Murayama, K, Shirouzu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-10
Release date:2007-07-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Aurora-A kinase complexed with AMPPNP
To be Published
2DS1
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Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor
Descriptor: (13R,15S)-13-METHYL-16-OXA-8,9,12,22,24-PENTAAZAHEXACYCLO[15.6.2.16,9.1,12,15.0,2,7.0,21,25]HEPTACOSA-1(24),2,4,6,17(25 ),18,20-HEPTAENE-23,26-DIONE, Cell division protein kinase 2
Authors:Ikuta, M.
Deposit date:2006-06-17
Release date:2007-06-19
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure
Bioorg.Med.Chem.Lett., 16, 2006
2B9F
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BU of 2b9f by Molmil
Crystal structure of non-phosphorylated Fus3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3
Authors:Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:2005-10-11
Release date:2006-01-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
Mol.Cell, 20, 2005
2B1P
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BU of 2b1p by Molmil
inhibitor complex of JNK3
Descriptor: 3-{6-[(2-CHLOROPHENYL)AMINO]-1H-INDAZOL-3-YL}-5-{[4-(DIMETHYLAMINO)BUTANOYL]AMINO}BENZOIC ACID, BETA-MERCAPTOETHANOL, Mitogen-activated protein kinase 10, ...
Authors:Swahn, B.M, Huerta, F, Kallin, E, Malmstrom, J, Weigelt, T, Viklund, J, Womack, P, Xue, Y, Ohberg, L.
Deposit date:2005-09-16
Release date:2006-09-16
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3
Bioorg.Med.Chem.Lett., 15, 2005
2B52
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Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562
Descriptor: 1-(3-(2,4-DIMETHYLTHIAZOL-5-YL)-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)-3-(4-METHYLPIPERAZIN-1-YL)UREA, Cell division protein kinase 2
Authors:Muckelbauer, J.
Deposit date:2005-09-27
Release date:2005-10-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. Part 4: Heterocycles at C3
Bioorg.Med.Chem.Lett., 14, 2004
2BAL
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BU of 2bal by Molmil
p38alpha MAP kinase bound to pyrazoloamine
Descriptor: Mitogen-activated protein kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE
Authors:Gerhardt, S, Pauptit, R.A, Read, J, Tucker, J, Norman, R.A, Breed, J.
Deposit date:2005-10-14
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase.
Biochemistry, 44, 2005
2B9J
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Crystal structure of Fus3 with a docking motif from Far1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cyclin-dependent kinase inhibitor FAR1, MAGNESIUM ION, ...
Authors:Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:2005-10-11
Release date:2006-01-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
Mol.Cell, 20, 2005
2B53
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Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325
Descriptor: 6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE, Cell division protein kinase 2
Authors:Muckelbauer, J.
Deposit date:2005-09-27
Release date:2005-10-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Quinazolines as Cyclin Dependent Kinase Inhibitors
Bioorg.Med.Chem.Lett., 11, 2001
2BAK
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BU of 2bak by Molmil
p38alpha MAP kinase bound to MPAQ
Descriptor: Mitogen-activated protein kinase 14, N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-YLETHOXY)QUINAZOLIN-4-YL]AMINO}-4-METHYLPHENYL)-2-MORPHOLIN-4-YLISONICOTINAMIDE
Authors:Gerhardt, S, Breed, J, Pauptit, R.A, Read, J, Norman, R.A, Ward, W.H.
Deposit date:2005-10-14
Release date:2005-12-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase
Biochemistry, 44, 2005
2B55
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Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole DIN-101312
Descriptor: 2-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3_CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDE, Cell division protein kinase 2
Authors:Muckelbauer, J.
Deposit date:2005-09-27
Release date:2005-10-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3
J.Med.Chem., 45, 2002
2BAJ
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p38alpha bound to pyrazolourea
Descriptor: 1-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2,3-dichlorophenyl)urea, Mitogen-activated protein kinase 14
Authors:Gerhardt, S, Pauptit, R.A, Read, J, Breed, J, Norman, R.A, Ward, W.H.
Deposit date:2005-10-14
Release date:2005-12-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase
Biochemistry, 44, 2005
2B54
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Human cyclin dependent kinase 2 (CKD2)complexed with DIN-232305
Descriptor: 6-(3,4-DIHYDROXYBENZYL)-3-ETHYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE, Cell division protein kinase 2
Authors:Chang, C.-C.
Deposit date:2005-09-27
Release date:2005-10-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1h-pyraxolo[3,4-d]pyrimidin-4-one inhibitors of cyclin dependent kinases
J.Med.Chem., 47, 2004

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