2DUV

Structure of CDK2 with a 3-hydroxychromones

Summary for 2DUV

Entry DOI	10.2210/pdb2duv/pdb
Descriptor	Cell division protein kinase 2, 2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONE (3 entities in total)
Functional Keywords	protein kinase, serine/threonine-protein kinase, cell division, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34379.89
Authors	Kim, K.H.,Lee, J.,Park, T.,Jeong, S.,Hong, C. (deposition date: 2006-07-27, release date: 2007-01-27, Last modification date: 2024-03-13)
Primary citation	Lee, J.,Park, T.,Jeong, S.,Kim, K.H.,Hong, C. 3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation. Bioorg.Med.Chem.Lett., 17:1284-1287, 2007 Cited by PubMed: 17178224 DOI: 10.1016/j.bmcl.2006.12.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation