3JC7
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![BU of 3jc7 by Molmil](/molmil-images/mine/3jc7) | Structure of the eukaryotic replicative CMG helicase and pumpjack motion | Descriptor: | Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | Authors: | Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E. | Deposit date: | 2015-11-24 | Release date: | 2016-02-10 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat.Struct.Mol.Biol., 23, 2016
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7JM4
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![BU of 7jm4 by Molmil](/molmil-images/mine/7jm4) | IRF Transcription Factor | Descriptor: | Interferon regulatory factor 4, Interferon-Stimulated Response Elements | Authors: | Sundararaj, S, Williams, S.J, Casarotto, M.G. | Deposit date: | 2020-07-31 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural determinants of the IRF4/DNA homodimeric complex. Nucleic Acids Res., 49, 2021
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7JX1
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![BU of 7jx1 by Molmil](/molmil-images/mine/7jx1) | E. coli TSase complex with a bi-substrate reaction intermediate analog | Descriptor: | (2S)-2-({4-[({(6R)-2,4-diamino-5-[(1-{(2R,4S,5R)-4-hydroxy-5-[(phosphonooxy)methyl]tetrahydrofuran-2-yl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl}methyl)amino]benzoyl}amino)pentanedioic acid (non-preferred name), N-(4-{[(2,4-diamino-7,8-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino}benzene-1-carbonyl)-L-glutamic acid, PHOSPHATE ION, ... | Authors: | Finer-Moore, J, Kholodar, S.A, Stroud, R.M, Kohen, A. | Deposit date: | 2020-08-26 | Release date: | 2021-04-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog. Biochemistry, 60, 2021
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7JXF
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![BU of 7jxf by Molmil](/molmil-images/mine/7jxf) | E. coli TSase complex with a bi-substrate reaction intermediate diastereomer analog | Descriptor: | (2S)-2-({4-[({(6S)-2,4-diamino-5-[(1-{(2R,4S,5R)-4-hydroxy-5-[(phosphonooxy)methyl]tetrahydrofuran-2-yl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl}methyl)amino]benzoyl}amino)pentanedioic acid (non-preferred name), 5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE, N-[4-({[(6S)-2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl]methyl}amino)benzene-1-carbonyl]-L-glutamic acid, ... | Authors: | Finer-Moore, J, Kholodar, S.A, Stroud, R.M, Kohen, A, Moliner, V, Swiderek, K. | Deposit date: | 2020-08-27 | Release date: | 2021-04-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog. Biochemistry, 60, 2021
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7L18
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![BU of 7l18 by Molmil](/molmil-images/mine/7l18) | Crystal structure of a tandem deletion mutant of rat NADPH-cytochrome P450 reductase | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Hubbard, P.A, Xia, C, Shen, A.L, Kim, J.J.K. | Deposit date: | 2020-12-14 | Release date: | 2021-01-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.542 Å) | Cite: | Structural and kinetic investigations of the carboxy terminus of NADPH-cytochrome P450 oxidoreductase. Arch.Biochem.Biophys., 701, 2021
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7KQ7
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![BU of 7kq7 by Molmil](/molmil-images/mine/7kq7) | Crystal structure of IL21R in complex with an antibody Fab fragment | Descriptor: | Antibody heavy chain, Antibody light chain, Interleukin-21 receptor | Authors: | Mosyak, L, Svenson, K. | Deposit date: | 2020-11-13 | Release date: | 2021-04-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.203 Å) | Cite: | Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody. Mabs, 13, 2021
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7JTQ
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7LEW
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![BU of 7lew by Molmil](/molmil-images/mine/7lew) | Crystal structure of UBE2G2 in complex with the UBE2G2-binding region of AUP1 | Descriptor: | Lipid droplet-regulating VLDL assembly factor AUP1, Ubiquitin-conjugating enzyme E2 G2 | Authors: | Liang, Y.-H, Smith, C.E, Tsai, Y.C, Weissman, A.M, Ji, X. | Deposit date: | 2021-01-15 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.736 Å) | Cite: | A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation. Plos Biol., 19, 2021
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7MFR
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![BU of 7mfr by Molmil](/molmil-images/mine/7mfr) | Crystal Structure of a Fab fragment bound to peptide GGM | Descriptor: | Antibody fragment - Heavy Chain of fab, Antibody fragment - Light Chain of fab, GLY-GLY-MET, ... | Authors: | Sudhamsu, J. | Deposit date: | 2021-04-10 | Release date: | 2021-06-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.848 Å) | Cite: | Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W. Nat Commun, 12, 2021
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7JTN
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7LKI
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7LKQ
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![BU of 7lkq by Molmil](/molmil-images/mine/7lkq) | The PilZ(delta107-117)-FimX(GGDEF-EAL) complex from Xanthomonas citri | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), FimX(GGDEF-EAL), MAGNESIUM ION, ... | Authors: | Llontop, E.E, Guzzo, C.R, Farah, C.S. | Deposit date: | 2021-02-02 | Release date: | 2021-08-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | The PilB-PilZ-FimX regulatory complex of the Type IV pilus from Xanthomonas citri. Plos Pathog., 17, 2021
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7LKO
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7LKN
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7LKM
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3AL2
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![BU of 3al2 by Molmil](/molmil-images/mine/3al2) | Crystal Structure of TopBP1 BRCT7/8 | Descriptor: | DNA topoisomerase 2-binding protein 1, SULFATE ION | Authors: | Leung, C.C, Glover, J.N. | Deposit date: | 2010-07-22 | Release date: | 2010-12-01 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control J.Biol.Chem., 286, 2011
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3AKJ
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3ANT
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![BU of 3ant by Molmil](/molmil-images/mine/3ant) | Human soluble epoxide hydrolase in complex with a synthetic inhibitor | Descriptor: | 4-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-N-[(1S,2R)-2-phenylcyclopropyl]piperidine-1-carboxamide, Epoxide hydrolase 2 | Authors: | Chiyo, N, Ishii, T, Hourai, S, Yanagi, K. | Deposit date: | 2010-09-08 | Release date: | 2011-01-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors J.Med.Chem., 54, 2011
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3ANO
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![BU of 3ano by Molmil](/molmil-images/mine/3ano) | Crystal Structure of a Novel Diadenosine 5',5'''-P1,P4-Tetraphosphate Phosphorylase from Mycobacterium tuberculosis H37Rv | Descriptor: | AP-4-A phosphorylase, PHOSPHATE ION, TETRAETHYLENE GLYCOL | Authors: | Mori, S, Shibayama, K, Wachino, J, Arakawa, Y. | Deposit date: | 2010-09-06 | Release date: | 2011-05-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.894 Å) | Cite: | Structural insights into the novel diadenosine 5',5-P1,P4-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv J.Mol.Biol., 410, 2011
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3ANS
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![BU of 3ans by Molmil](/molmil-images/mine/3ans) | Human soluble epoxide hydrolase in complex with a synthetic inhibitor | Descriptor: | 4-cyano-N-[(1S,2R)-2-phenylcyclopropyl]benzamide, Epoxide hydrolase 2 | Authors: | Chiyo, N, Ishii, T, Hourai, S, Yanagi, K. | Deposit date: | 2010-09-08 | Release date: | 2011-01-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors J.Med.Chem., 54, 2011
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3AKL
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3AKK
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3AL5
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![BU of 3al5 by Molmil](/molmil-images/mine/3al5) | Crystal structure of Human TYW5 | Descriptor: | JmjC domain-containing protein C2orf60, MAGNESIUM ION | Authors: | Kato, M, Araiso, Y, Ishitani, R, Nureki, O. | Deposit date: | 2010-07-26 | Release date: | 2010-11-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. Nucleic Acids Res., 39, 2011
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3AOB
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3AM1
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![BU of 3am1 by Molmil](/molmil-images/mine/3am1) | Crystal structure of O-Phosphoseryl-tRNA kinase complexed with anticodon-stem/loop truncated tRNA(Sec) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ASL-truncated tRNA, L-seryl-tRNA(Sec) kinase, ... | Authors: | Araiso, Y, Ishitani, R, Nureki, O. | Deposit date: | 2010-08-11 | Release date: | 2010-12-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | C-terminal domain of archaeal O-phosphoseryl-tRNA kinase displays large-scale motion to bind the 7-bp D-stem of archaeal tRNA(Sec) Nucleic Acids Res., 39, 2011
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