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3ANS

Human soluble epoxide hydrolase in complex with a synthetic inhibitor

Summary for 3ANS
Entry DOI10.2210/pdb3ans/pdb
Related3ANT
DescriptorEpoxide hydrolase 2, 4-cyano-N-[(1S,2R)-2-phenylcyclopropyl]benzamide (3 entities in total)
Functional Keywordshydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P34913
Total number of polymer chains2
Total formula weight77817.46
Authors
Chiyo, N.,Ishii, T.,Hourai, S.,Yanagi, K. (deposition date: 2010-09-08, release date: 2011-01-19, Last modification date: 2023-11-01)
Primary citationTanaka, D.,Tsuda, Y.,Shiyama, T.,Nishimura, T.,Chiyo, N.,Tominaga, Y.,Sawada, N.,Mimoto, T.,Kusunose, N.
A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors
J.Med.Chem., 54:851-857, 2011
Cited by
PubMed: 21192659
DOI: 10.1021/jm101273e
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.98 Å)
Structure validation

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