7JXF
E. coli TSase complex with a bi-substrate reaction intermediate diastereomer analog
Summary for 7JXF
Entry DOI | 10.2210/pdb7jxf/pdb |
Descriptor | Thymidylate synthase, 5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE, N-[4-({[(6S)-2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl]methyl}amino)benzene-1-carbonyl]-L-glutamic acid, ... (6 entities in total) |
Functional Keywords | non covalent intermediate, half-sites activity, tmp synthesis, inhibitor, biosynthetic protein |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 62733.61 |
Authors | Finer-Moore, J.,Kholodar, S.A.,Stroud, R.M.,Kohen, A.,Moliner, V.,Swiderek, K. (deposition date: 2020-08-27, release date: 2021-04-21, Last modification date: 2023-10-18) |
Primary citation | Kholodar, S.A.,Finer-Moore, J.S.,Swiderek, K.,Arafet, K.,Moliner, V.,Stroud, R.M.,Kohen, A. Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog. Biochemistry, 60:1243-1247, 2021 Cited by PubMed: 33829766DOI: 10.1021/acs.biochem.1c00063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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