7JXF

E. coli TSase complex with a bi-substrate reaction intermediate diastereomer analog

Summary for 7JXF

• Entry DOI: 10.2210/pdb7jxf/pdb
• Descriptor: Thymidylate synthase, 5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE, N-[4-({[(6S)-2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl]methyl}amino)benzene-1-carbonyl]-L-glutamic acid, ... (6 entities in total)
• Functional Keywords: non covalent intermediate, half-sites activity, tmp synthesis, inhibitor, biosynthetic protein
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 62733.61

Authors

Finer-Moore, J.,Kholodar, S.A.,Stroud, R.M.,Kohen, A.,Moliner, V.,Swiderek, K. (deposition date: 2020-08-27, release date: 2021-04-21, Last modification date: 2023-10-18)

• Primary citation: Kholodar, S.A.,Finer-Moore, J.S.,Swiderek, K.,Arafet, K.,Moliner, V.,Stroud, R.M.,Kohen, A.; Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog.; Biochemistry, 60:1243-1247, 2021; PubMed: 33829766; DOI: 10.1021/acs.biochem.1c00063

Experimental method

X-RAY DIFFRACTION (1.5 Å)