7KQ7

Crystal structure of IL21R in complex with an antibody Fab fragment

Summary for 7KQ7

• Entry DOI: 10.2210/pdb7kq7/pdb
• Descriptor: Antibody heavy chain, Antibody light chain, Interleukin-21 receptor, ... (4 entities in total)
• Functional Keywords: cytokine receptor, protein binding, protein binding-immune system complex, protein binding/immune system
• Biological source: Rattus norvegicus; More
• Total number of polymer chains: 3
• Total formula weight: 72262.60

Authors

Mosyak, L.,Svenson, K. (deposition date: 2020-11-13, release date: 2021-04-07, Last modification date: 2024-04-03)

• Primary citation: Campbell, S.M.,DeBartolo, J.,Apgar, J.R.,Mosyak, L.,McManus, V.,Beyer, S.,Bennett, E.M.,Lambert, M.,Cunningham, O.; Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody.; Mabs, 13:1883239-1883239, 2021; PubMed: 33557673; DOI: 10.1080/19420862.2021.1883239

Experimental method

X-RAY DIFFRACTION (2.203 Å)