7LEW

Crystal structure of UBE2G2 in complex with the UBE2G2-binding region of AUP1

Summary for 7LEW

• Entry DOI: 10.2210/pdb7lew/pdb
• Descriptor: Ubiquitin-conjugating enzyme E2 G2, Lipid droplet-regulating VLDL assembly factor AUP1 (3 entities in total)
• Functional Keywords: alpha beta, ligase, ligase-transferase complex, ligase/transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 22773.85

Authors

Liang, Y.-H.,Smith, C.E.,Tsai, Y.C.,Weissman, A.M.,Ji, X. (deposition date: 2021-01-15, release date: 2021-11-10, Last modification date: 2023-10-18)

• Primary citation: Smith, C.E.,Tsai, Y.C.,Liang, Y.H.,Khago, D.,Mariano, J.,Li, J.,Tarasov, S.G.,Gergel, E.,Tsai, B.,Villaneuva, M.,Clapp, M.E.,Magidson, V.,Chari, R.,Byrd, R.A.,Ji, X.,Weissman, A.M.; A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation.; Plos Biol., 19:e3001474-e3001474, 2021; PubMed: 34879065; DOI: 10.1371/journal.pbio.3001474

Experimental method

X-RAY DIFFRACTION (1.736 Å)