3ANT
Human soluble epoxide hydrolase in complex with a synthetic inhibitor
Summary for 3ANT
| Entry DOI | 10.2210/pdb3ant/pdb |
| Related | 3ANS |
| Descriptor | Epoxide hydrolase 2, 4-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-N-[(1S,2R)-2-phenylcyclopropyl]piperidine-1-carboxamide (3 entities in total) |
| Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P34913 |
| Total number of polymer chains | 2 |
| Total formula weight | 78001.74 |
| Authors | Chiyo, N.,Ishii, T.,Hourai, S.,Yanagi, K. (deposition date: 2010-09-08, release date: 2011-01-19, Last modification date: 2023-11-01) |
| Primary citation | Tanaka, D.,Tsuda, Y.,Shiyama, T.,Nishimura, T.,Chiyo, N.,Tominaga, Y.,Sawada, N.,Mimoto, T.,Kusunose, N. A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors J.Med.Chem., 54:851-857, 2011 Cited by PubMed: 21192659DOI: 10.1021/jm101273e PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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