3ANT

Human soluble epoxide hydrolase in complex with a synthetic inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Epoxide hydrolase 2	polymer	336	38646.4	2	UniProt (P34913) Pfam (PF00561)	Homo sapiens (human)	Soluble epoxide hydrolase, SEH, Epoxide hydratase, Cytosolic epoxide hydrolase, CEH
2	C, D (A, B)	4-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-N-[(1S,2R)-2-phenylcyclopropyl]piperidine-1-carboxamide	non-polymer		354.4	2	Chemie (S82)
3	E, F (A, B)	water	water		18.0	121	Chemie (HOH)

Sequence modifications

A, B: 230 - 555 (UniProt: P34913)

PDB	External Database	Details
Met 220	-	expression tag
Lys 221	-	expression tag
Lys 222	-	expression tag
Gly 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77292.8
Non-Polymers*	Number of molecules	2
	Total formula weight	708.9
All*	Total formula weight	78001.7

*Water molecules are not included.