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7PDW	Crystal structure of parent TCR (728) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide Descriptor: Beta-2-microglobulin, GLYCEROL, MHC class I antigen, ... Authors: Simister, P.C, Border, E.C, Vieira, J.F, Pumphrey, N.J. Deposit date: 2021-08-09 Release date: 2022-08-03 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy. J Immunother Cancer, 10, 2022
7UR1	SARS-CoV-2 Spike-derived peptide S1215-1224 (YIWLGFIAGL) presented by HLA-A*02:01 Descriptor: Beta-2-microglobulin, HLA class I antigen, SARS-CoV-2 Spike-derived peptide S1215-1224 (YIWLGFIAGL) Authors: Szeto, C, Ahn, Y.M, Gras, S. Deposit date: 2022-04-21 Release date: 2023-04-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.17 Å) Cite: SARS-CoV-2 Spike-derived peptide S1215-1224 (YIWLGFIAGL) presented by HLA-A*02:01 To Be Published
7UM2	SARS-CoV-2 Spike-derived peptide S417-425 K417T mutant (TIADYNYKL) presented by HLA-A*02:01 Descriptor: Beta-2-microglobulin, CADMIUM ION, HLA class I antigen, ... Authors: Szeto, C, Gras, S. Deposit date: 2022-04-06 Release date: 2023-04-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.63 Å) Cite: SARS-CoV-2 Spike-derived peptide S417-425 K417T mutant (TIADYNYKL) presented by HLA-A*02:01 To Be Published
7QNG	Structure of a MHC I-Tapasin-ERp57 complex Descriptor: Beta-2-microglobulin, H-2 class I histocompatibility antigen, D-B alpha chain, ... Authors: Mueller, I.K, Thomas, C, Trowitzsch, S, Tampe, R. Deposit date: 2021-12-20 Release date: 2022-09-28 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure of an MHC I-tapasin-ERp57 editing complex defines chaperone promiscuity. Nat Commun, 13, 2022
7QPD	Structure of the human MHC I peptide-loading complex editing module Descriptor: Beta-2-microglobulin, Calreticulin, HLA class I histocompatibility antigen, ... Authors: Domnick, A, Susac, L, Trowitzsch, S, Thomas, C, Tampe, R. Deposit date: 2022-01-03 Release date: 2022-07-20 Last modified: 2022-08-24 Method: ELECTRON MICROSCOPY (3.73 Å) Cite: Molecular basis of MHC I quality control in the peptide loading complex. Nat Commun, 13, 2022
7QPJ	Crystal structure of engineered TCR (756) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide Descriptor: Beta-2-microglobulin, GLYCEROL, MHC class I antigen, ... Authors: Simister, P.C, Border, E.C, Vieira, J.F, Pumphrey, N.J. Deposit date: 2022-01-04 Release date: 2022-08-03 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy. J Immunother Cancer, 10, 2022
4EUP	The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... Authors: Hossain, M, Baker, B.M. Deposit date: 2012-04-25 Release date: 2013-05-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.88 Å) Cite: Structural description of how different MART-1 antigenic peptides influence JKF6 T cell receptor recognition To be Published
7UC5	Crystal Structure of HLA A*0301 in complex with ILRGSVAHK, a 9-mer epitope from Influenza A Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A alpha chain, ... Authors: Gras, S, Nguyen, A.T, Szeto, C. Deposit date: 2022-03-16 Release date: 2022-10-12 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.95 Å) Cite: CD8+ T cells cross-recognise conserved influenza A and B homologous epitopes to be published
7UMG	Crystal structure of human CD8aa-MR1-Ac-6-FP complex Descriptor: Beta-2-microglobulin, CHLORIDE ION, Major histocompatibility complex class I-related gene protein, ... Authors: Awad, W, Rossjohn, J. Deposit date: 2022-04-06 Release date: 2022-08-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.4 Å) Cite: CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells. J.Exp.Med., 219, 2022
5NQK	human 199.16 TCR in complex with Melan-A/MART-1 (26-35) peptide and HLA-A2 Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... Authors: Exertier, C, Reiser, J.-B, Lantez, V, Chouquet, A, Bonneville, M, Saulquin, X, Housset, D. Deposit date: 2017-04-20 Release date: 2018-05-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.25 Å) Cite: human 199.16 TCR in complex with Melan-A/MART-1 (26-35) peptide and HLA-A2 To Be Published
7UFJ	Structure of human MR1-ethylvanillin in complex with human MAIT A-F7 TCR Descriptor: 3-ethoxy-4-hydroxybenzaldehyde, ACETATE ION, Beta-2-microglobulin, ... Authors: Wang, C.J, Rossjohn, J, Le Nours, J. Deposit date: 2022-03-22 Release date: 2022-12-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Quantitative affinity measurement of small molecule ligand binding to Major Histocompatibility Complex class-I related protein 1 MR1. J.Biol.Chem., 298, 2022
4E5X	Crystal structure of a complex between the human adenovirus type 2 E3-19K protein and MHC class I molecule HLA-A2/Tax Descriptor: Beta-2-microglobulin, Early E3 18.5 kDa glycoprotein, HLA class I histocompatibility antigen, ... Authors: Li, L, Bouvier, M. Deposit date: 2012-03-14 Release date: 2012-10-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure of adenovirus E3-19K bound to HLA-A2 reveals mechanism for immunomodulation. Nat.Struct.Mol.Biol., 19, 2012
4EN3	Crystal structure of a human Valpha24(-) NKT TCR in complex with CD1d/alpha-galactosylceramide Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d, Beta-2-microglobulin, ... Authors: Lopez-Sagaseta, J, Adams, E.J. Deposit date: 2012-04-12 Release date: 2012-10-31 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.568 Å) Cite: The Molecular Basis for Recognition of CD1d/alpha-Galactosylceramide by a Human Non-Valpha24 T Cell Receptor Struct. Title Plos Biol., 10, 2012
7XF3	The structure of HLA-B*1501/BM58-66AF9 Descriptor: 9-mer peptide from Matrix protein 1, Beta-2-microglobulin, MHC class I antigen Authors: Zhao, Y.Z, Xiao, W.L, Wu, Y.N, Fan, W.F, Yue, C, Zhang, Q.X, Zhang, D.N, Yuan, X.J, Yao, S.J, Liu, S, Li, M, Wang, P.Y, Zhang, H.J, Zhang, J, Zhao, M, Zheng, X.Q, Liu, W.J, Gao, G.F, Liu, W.L. Deposit date: 2022-03-31 Release date: 2023-02-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Parallel T Cell Immunogenic Regions in Influenza B and A Viruses with Distinct Nuclear Export Signal Functions: The Balance between Viral Life Cycle and Immune Escape. J Immunol., 210, 2023
5OPI	Crystal structure of the TAPBPR-MHC I peptide editing complex Descriptor: Beta-2-microglobulin, H-2 class I histocompatibility antigen, D-B alpha chain, ... Authors: Thomas, C, Tampe, R. Deposit date: 2017-08-09 Release date: 2017-10-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structure of the TAPBPR-MHC I complex defines the mechanism of peptide loading and editing. Science, 358, 2017
7WZZ	Crystal structure of peptide KAGQVVTIW in complex with HLA-B5801 Descriptor: Beta-2-microglobulin, GLYCEROL, LYS-ALA-GLY-GLN-VAL-VAL-THR-ILE-TRP, ... Authors: Huan, X, Ren, E.C. Deposit date: 2022-02-20 Release date: 2023-05-03 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.305 Å) Cite: Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01. Sci Rep, 13, 2023
7X00	Crystal structure of peptide VSFIEFVGW in complex with HLA-B5801 Descriptor: Beta-2-microglobulin, GLYCEROL, MHC class I antigen, ... Authors: Huan, X, Ren, E.C. Deposit date: 2022-02-20 Release date: 2023-05-03 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01. Sci Rep, 13, 2023
7X1B	Crystal structure of peptide KAGQVVTI in complex with HLA-B5801 Descriptor: Beta-2-microglobulin, GLYCEROL, HLA-B, ... Authors: Huan, X, Ren, E.C. Deposit date: 2022-02-23 Release date: 2023-05-03 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.399 Å) Cite: Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01. Sci Rep, 13, 2023
7X1C	Crystal structure of peptide VSFIEFVI in complex with HLA-B5801 Descriptor: Beta-2-microglobulin, GLYCEROL, HLA-B, ... Authors: Huan, X, Ren, E.C. Deposit date: 2022-02-23 Release date: 2023-05-03 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.409 Å) Cite: Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01. Sci Rep, 13, 2023
4F7T	Crystal Structure of HLA-A*2402 Complexed with a Newly Identified Peptide from 2009 H1N1 PB1 (498-505) Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... Authors: Liu, J, Zhang, S, Tan, S, Yi, Y, Wu, B, Zhu, F, Wang, H, Qi, J, Gao, G.F. Deposit date: 2012-05-16 Release date: 2012-10-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals. J.Virol., 86, 2012
6EQB	HLA class I histocompatibility antigen Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL, ... Authors: Rizkallah, P.J, Cole, D.K. Deposit date: 2017-10-12 Release date: 2018-10-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.81 Å) Cite: TCR-induced alteration of primary MHC peptide anchor residue. Eur.J.Immunol., 49, 2019
6ENY	Structure of the human PLC editing module Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Calreticulin, ... Authors: Trowitzsch, S, Januliene, D, Blees, A, Moeller, A, Tampe, R. Deposit date: 2017-10-07 Release date: 2017-11-29 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: Structure of the human MHC-I peptide-loading complex. Nature, 551, 2017
6RPB	Crystal structure of the T-cell receptor NYE_S1 bound to HLA A2*01-SLLMWITQV Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... Authors: Coles, C.H, Mulvaney, R, Malla, S, Lloyd, A, Smith, K, Chester, F, Knox, A, Stacey, A.R, Dukes, J, Baston, E, Griffin, S, Vuidepot, A, Jakobsen, B.K, Harper, S. Deposit date: 2019-05-14 Release date: 2020-01-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.5 Å) Cite: TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide-HLA Complex. J Immunol., 204, 2020
6RP9	Crystal structure of the T-cell receptor NYE_S3 bound to HLA A2*01-SLLMWITQV Descriptor: Beta-2-microglobulin, Cancer/testis antigen 1, HLA class I histocompatibility antigen, ... Authors: Coles, C.H, Mulvaney, R, Malla, S, Lloyd, A, Smith, K, Chester, F, Knox, A, Stacey, A.R, Dukes, J, Baston, E, Griffin, S, Vuidepot, A, Jakobsen, B.K, Harper, S. Deposit date: 2019-05-14 Release date: 2020-01-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.12 Å) Cite: TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide-HLA Complex. J Immunol., 204, 2020
6EQA	HLA class I histocompatibility antigen Descriptor: ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... Authors: Rizkallah, P.J, Cole, D.K. Deposit date: 2017-10-12 Release date: 2018-10-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.16 Å) Cite: TCR-induced alteration of primary MHC peptide anchor residue. Eur.J.Immunol., 49, 2019

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