7QPJ

Crystal structure of engineered TCR (756) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide

Summary for 7QPJ

• Entry DOI: 10.2210/pdb7qpj/pdb
• Related: 7PBC 7PDW 7PDX
• Descriptor: MHC class I antigen, Beta-2-microglobulin, Melanoma-associated antigen 10, ... (7 entities in total)
• Functional Keywords: t-cell receptor, human leukocyte antigen, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 95289.79

Authors

Simister, P.C.,Border, E.C.,Vieira, J.F.,Pumphrey, N.J. (deposition date: 2022-01-04, release date: 2022-08-03, Last modification date: 2024-01-31)

• Primary citation: Simister, P.C.,Border, E.C.,Vieira, J.F.,Pumphrey, N.J.; Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.; J Immunother Cancer, 10:-, 2022; PubMed: 35851311; DOI: 10.1136/jitc-2022-004600

Experimental method

X-RAY DIFFRACTION (1.54 Å)