7PBC

Crystal structure of engineered TCR (796) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide

This is a non-PDB format compatible entry.

Summary for 7PBC

• Entry DOI: 10.2210/pdb7pbc/pdb
• Descriptor: MHC class I antigen, Beta-2-microglobulin, T-cell receptor (TRAV/TRAC), ... (8 entities in total)
• Functional Keywords: t-cell receptor, human leukocyte antigen, immunoglobulin fold, complex, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 95298.22

Authors

Simister, P.C.,Border, E.C.,Vieira, J.F.,Pumphrey, N.J. (deposition date: 2021-08-02, release date: 2022-08-03, Last modification date: 2024-01-31)

• Primary citation: Simister, P.C.,Border, E.C.,Vieira, J.F.,Pumphrey, N.J.; Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.; J Immunother Cancer, 10:-, 2022; PubMed: 35851311; DOI: 10.1136/jitc-2022-004600

Experimental method

X-RAY DIFFRACTION (2.04 Å)