7QPJ
Crystal structure of engineered TCR (756) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | MHC class I antigen | polymer | 277 | 32082.5 | 1 | UniProt (Q861F7) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (A0A140T913) | Homo sapiens (human) | |
| 2 | B (D) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C (E) | Melanoma-associated antigen 10 | polymer | 9 | 1035.2 | 1 | UniProt (P43363) | Homo sapiens | Cancer/testis antigen 1.10,CT1.10,MAGE-10 antigen |
| 4 | D (A) | T-cell receptor alpha chain | polymer | 206 | 22761.0 | 1 | Homo sapiens (Human) | ||
| 5 | E (B) | T-cell receptor beta chain | polymer | 241 | 27163.4 | 1 | Homo sapiens (Human) | ||
| 6 | F, G, H, I (C) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 7 | J, K, L, M, N (C, D, E, A, B) | water | water | 18.0 | 528 | Chemie (HOH) |
Sequence modifications
C: 2 - 277 (UniProt: Q861F7)
D: 2 - 100 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94921.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 368.4 | |
| All* | Total formula weight | 95289.8 |
