7UMG

Crystal structure of human CD8aa-MR1-Ac-6-FP complex

Summary for 7UMG

• Entry DOI: 10.2210/pdb7umg/pdb
• Descriptor: Major histocompatibility complex class I-related gene protein, Beta-2-microglobulin, T-cell surface glycoprotein CD8 alpha chain, ... (7 entities in total)
• Functional Keywords: cd8 coreceptor, mr1, metabolite presentation, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 72795.20

Authors

Awad, W.,Rossjohn, J. (deposition date: 2022-04-06, release date: 2022-08-03, Last modification date: 2023-10-18)

• Primary citation: Souter, M.N.T.,Awad, W.,Li, S.,Pediongco, T.J.,Meehan, B.S.,Meehan, L.J.,Tian, Z.,Zhao, Z.,Wang, H.,Nelson, A.,Le Nours, J.,Khandokar, Y.,Praveena, T.,Wubben, J.,Lin, J.,Sullivan, L.C.,Lovrecz, G.O.,Mak, J.Y.W.,Liu, L.,Kostenko, L.,Kedzierska, K.,Corbett, A.J.,Fairlie, D.P.,Brooks, A.G.,Gherardin, N.A.,Uldrich, A.P.,Chen, Z.,Rossjohn, J.,Godfrey, D.I.,McCluskey, J.,Pellicci, D.G.,Eckle, S.B.G.; CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells.; J.Exp.Med., 219:-, 2022; PubMed: 36018322; DOI: 10.1084/jem.20210828

Experimental method

X-RAY DIFFRACTION (2.4 Å)