6RPB

Crystal structure of the T-cell receptor NYE_S1 bound to HLA A2*01-SLLMWITQV

Summary for 6RPB

• Entry DOI: 10.2210/pdb6rpb/pdb
• Related: 6RP9 6RPA
• Descriptor: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Heteroclitic NY-ESO-1 157-165 peptide, ... (6 entities in total)
• Functional Keywords: t-cell receptor, peptide-human leukocyte antigen complex, ny-eso-1, cancer testis antigen, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 20
• Total formula weight: 381187.40

Authors

Coles, C.H.,Mulvaney, R.,Malla, S.,Lloyd, A.,Smith, K.,Chester, F.,Knox, A.,Stacey, A.R.,Dukes, J.,Baston, E.,Griffin, S.,Vuidepot, A.,Jakobsen, B.K.,Harper, S. (deposition date: 2019-05-14, release date: 2020-01-15, Last modification date: 2024-01-24)

• Primary citation: Coles, C.H.,Mulvaney, R.M.,Malla, S.,Walker, A.,Smith, K.J.,Lloyd, A.,Lowe, K.L.,McCully, M.L.,Martinez Hague, R.,Aleksic, M.,Harper, J.,Paston, S.J.,Donnellan, Z.,Chester, F.,Wiederhold, K.,Robinson, R.A.,Knox, A.,Stacey, A.R.,Dukes, J.,Baston, E.,Griffin, S.,Jakobsen, B.K.,Vuidepot, A.,Harper, S.; TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide-HLA Complex.; J Immunol., 204:1943-1953, 2020; PubMed: 32102902; DOI: 10.4049/jimmunol.1900915

Experimental method

X-RAY DIFFRACTION (2.5 Å)