1CLM
 
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5J03
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1K93
 | | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin | | Descriptor: | CALCIUM ION, CALMODULIN, CALMODULIN-SENSITIVE ADENYLATE CYCLASE, ... | | Authors: | Drum, C.L, Yan, S.-Z, Bard, J, Shen, Y.-Q, Lu, D, Soelaiman, S, Grabarek, Z, Bohm, A, Tang, W.-J. | | Deposit date: | 2001-10-26 | | Release date: | 2002-01-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Nature, 415, 2002
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4V0C
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1K90
 | | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, CALMODULIN, ... | | Authors: | Drum, C.L, Yan, S.-Z, Bard, J, Shen, Y.-Q, Lu, D, Soelaiman, S, Grabarek, Z, Bohm, A, Tang, W.-J. | | Deposit date: | 2001-10-26 | | Release date: | 2002-01-23 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Nature, 415, 2002
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7SHQ
 | | Structure of a functional construct of eukaryotic elongation factor 2 kinase in complex with calmodulin. | | Descriptor: | CALCIUM ION, Calmodulin-1, Eukaryotic elongation factor 2 kinase,Eukaryotic elongation factor 2 kinase, ... | | Authors: | Piserchio, A, Isiorho, E.A, Jeruzalmi, D, Dalby, K.N, Ghose, R. | | Deposit date: | 2021-10-11 | | Release date: | 2022-04-06 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Structural basis for the calmodulin-mediated activation of eukaryotic elongation factor 2 kinase.
Sci Adv, 8, 2022
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8BD2
 | | Calcium-bound Calmodulin variant G113R | | Descriptor: | CALCIUM ION, Calmodulin-3 | | Authors: | Wimmer, R, Holler, C.V, Petersson, N.M, Iwai, H, Niemelae, M.A, Brohus, M, Overgaard, M.T. | | Deposit date: | 2022-10-18 | | Release date: | 2023-11-08 | | Last modified: | 2024-01-17 | | Method: | SOLUTION NMR | | Cite: | Allosteric changes in protein stability and dynamics as pathogenic mechanism for calmodulin variants not affecting Ca 2+ coordinating residues.
Cell Calcium, 117, 2023
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5J8H
 | | Structure of calmodulin in a complex with a peptide derived from a calmodulin-dependent kinase | | Descriptor: | CALCIUM ION, Calmodulin, Eukaryotic elongation factor 2 kinase | | Authors: | Alphonse, S, Lee, K, Piserchio, A, Tavares, C.D.J, Giles, D.H, Wellmann, R.M, Dalby, K.N, Ghose, R. | | Deposit date: | 2016-04-07 | | Release date: | 2016-09-07 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin.
Structure, 24, 2016
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2WEL
 | | Crystal structure of SU6656-bound calcium/calmodulin-dependent protein kinase II delta in complex with calmodulin | | Descriptor: | (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE, 1,2-ETHANEDIOL, CALCIUM ION, ... | | Authors: | Pike, A.C.W, Rellos, P, Salah, E, Burgess-Brown, N, Keates, T, Muniz, J, Sethi, R, Roos, A, Filippakopoulos, P, von Delft, F, Edwards, A, Weigelt, J, Arrowsmith, C.H, Bountra, C, Knapp, S. | | Deposit date: | 2009-03-31 | | Release date: | 2009-04-14 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.
Plos Biol., 8, 2010
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4Q5U
 | | Structure of calmodulin bound to its recognition site from calcineurin | | Descriptor: | CALCIUM ION, Calmodulin, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | | Authors: | Guo, H, Dunlap, T.B, Creamer, T.P, Vander Kooi, C.W. | | Deposit date: | 2014-04-17 | | Release date: | 2014-09-03 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Stoichiometry of the calcineurin regulatory domain-calmodulin complex.
Biochemistry, 53, 2014
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2X0G
 | | X-RAY STRUCTURE OF A DAP-KINASE CALMODULIN COMPLEX | | Descriptor: | CALCIUM ION, CALMODULIN, DEATH-ASSOCIATED PROTEIN KINASE 1, ... | | Authors: | Kuper, J, De Diego, I, Lehmann, F, Wilmanns, M. | | Deposit date: | 2009-12-08 | | Release date: | 2010-01-26 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Molecular Basis of the Death-Associated Protein Kinase-Calcium/Calmodulin Regulator Complex.
Sci.Signal, 3, 2010
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1UP5
 | | Chicken Calmodulin | | Descriptor: | CALCIUM ION, Calmodulin | | Authors: | Wilson, M.A, Rupp, B. | | Deposit date: | 2003-09-27 | | Release date: | 2005-03-24 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystallization and Preliminary X-Ray Analysis of Two New Crystal Forms of Calmodulin
Acta Crystallogr.,Sect.D, 52, 1996
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6T29
 | | Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 18 (CS587) | | Descriptor: | 1,2-ETHANEDIOL, 2-[(3~{S})-3-azanylpiperidin-1-yl]-4-[[3,5-bis(2-cyanopropan-2-yl)phenyl]amino]pyrimidine-5-carboxamide, Calcium/calmodulin-dependent protein kinase type 1D, ... | | Authors: | Kraemer, A, Sorrell, F, Butterworth, S, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2019-10-08 | | Release date: | 2019-11-13 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.484 Å) | | Cite: | Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesityin VivoMouse Model.
J.Med.Chem., 63, 2020
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6T28
 | | Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 19 (CS640) | | Descriptor: | 1,2-ETHANEDIOL, 2-[(3~{S})-3-azanylpiperidin-1-yl]-4-[[2,6-di(propan-2-yl)pyridin-4-yl]amino]pyrimidine-5-carboxamide, Calcium/calmodulin-dependent protein kinase type 1D, ... | | Authors: | Kraemer, A, Sorrell, F, Butterworth, S, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2019-10-08 | | Release date: | 2019-11-13 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesityin VivoMouse Model.
J.Med.Chem., 63, 2020
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1IWQ
 | | Crystal Structure of MARCKS calmodulin binding domain peptide complexed with Ca2+/Calmodulin | | Descriptor: | CALCIUM ION, CALMODULIN, MARCKS | | Authors: | Yamauchi, E, Nakatsu, T, Matsubara, M, Kato, H, Taniguchi, H, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2002-05-31 | | Release date: | 2003-03-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca(2+)-calmodulin
NAT.STRUCT.BIOL., 10, 2003
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1J7O
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1DEG
 | | THE LINKER OF DES-GLU84 CALMODULIN IS BENT AS SEEN IN THE CRYSTAL STRUCTURE | | Descriptor: | CALCIUM ION, CALMODULIN | | Authors: | Raghunathan, S, Chandross, R, Cheng, B.P, Persechini, A, Sobottk, S.E, Kretsinger, R.H. | | Deposit date: | 1993-06-07 | | Release date: | 1994-05-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The linker of des-Glu84-calmodulin is bent.
Proc.Natl.Acad.Sci.Usa, 90, 1993
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2FOT
 | | Crystal structure of the complex between calmodulin and alphaII-spectrin | | Descriptor: | CALCIUM ION, Calmodulin, alpha-II spectrin Spectrin | | Authors: | Simonovic, M, Zhang, Z, Cianci, C.D, Steitz, T.A, Morrow, J.S. | | Deposit date: | 2006-01-13 | | Release date: | 2006-09-05 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structure of the calmodulin alphaII-spectrin complex provides insight into the regulation of cell plasticity.
J.Biol.Chem., 281, 2006
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1MXE
 | | Structure of the Complex of Calmodulin with the Target Sequence of CaMKI | | Descriptor: | CALCIUM ION, Calmodulin, Target Sequence of rat Calmodulin-Dependent Protein Kinase I | | Authors: | Clapperton, J.A, Martin, S.R, Smerdon, S.J, Gamblin, S.J, Bayley, P.M. | | Deposit date: | 2002-10-02 | | Release date: | 2002-12-04 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of the Complex
of Calmodulin with the Target
Sequence of Calmodulin-Dependent
Protein Kinase I: Studies of the
Kinase Activation Mechanism
Biochemistry, 41, 2002
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1J7P
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1NWD
 | | Solution Structure of Ca2+/Calmodulin bound to the C-terminal Domain of Petunia Glutamate Decarboxylase | | Descriptor: | CALCIUM ION, Calmodulin, Glutamate decarboxylase | | Authors: | Yap, K.L, Yuan, T, Mal, T.K, Vogel, H.J, Ikura, M. | | Deposit date: | 2003-02-06 | | Release date: | 2003-04-08 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structural Basis for Simultaneous Binding of Two Carboxy-terminal Peptides
of Plant Glutamate Decarboxylase to Calmodulin
J.Mol.Biol., 328, 2003
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1L7Z
 | | Crystal structure of Ca2+/Calmodulin complexed with myristoylated CAP-23/NAP-22 peptide | | Descriptor: | CALCIUM ION, CALMODULIN, CAP-23/NAP-22, ... | | Authors: | Matsubara, M, Nakatsu, T, Yamauchi, E, Kato, H, Taniguchi, H, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2002-03-18 | | Release date: | 2003-09-16 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of a myristoylated CAP-23/NAP-22 N-terminal domain complexed with Ca2+/calmodulin
EMBO J., 23, 2004
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4UPU
 | | Crystal structure of IP3 3-K calmodulin binding region in complex with Calmodulin | | Descriptor: | CALCIUM ION, CALMODULIN, GLYCEROL, ... | | Authors: | Franco-Echevarria, E, Banos-Sanz, J.I, Monterroso, B, Round, A, Sanz-Aparicio, J, Gonzalez, B. | | Deposit date: | 2014-06-18 | | Release date: | 2014-08-20 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | A New Calmodulin Binding Motif for Inositol 1,4,5-Trisphosphate 3-Kinase Regulation.
Biochem.J., 463, 2014
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4EHQ
 | | Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+/Calmodulin Displays a Unique Binding Mode | | Descriptor: | CALCIUM ION, Calcium release-activated calcium channel protein 1, Calmodulin, ... | | Authors: | Liu, Y, Zheng, X, Mueller, G.A, Sobhany, M, DeRose, E.F, Zhang, Y, London, R.E, Birnbaumer, L. | | Deposit date: | 2012-04-03 | | Release date: | 2012-11-07 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.9005 Å) | | Cite: | Crystal structure of calmodulin binding domain of orai1 in complex with ca2+*calmodulin displays a unique binding mode.
J.Biol.Chem., 287, 2012
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1LVC
 | | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 2' deoxy, 3' anthraniloyl ATP | | Descriptor: | 3'ANTHRANILOYL-2'-DEOXY-ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, YTTERBIUM (III) ION, ... | | Authors: | Shen, Y, Lee, Y.-S, Soelaiman, S, Bergson, P, Lu, D, Chen, A, Beckingham, K, Grabarek, Z, Mrksich, M, Tang, W.-J. | | Deposit date: | 2002-05-28 | | Release date: | 2002-12-04 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
Embo J., 21, 2002
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