6T29

Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 18 (CS587)

This is a non-PDB format compatible entry.

Summary for 6T29

• Entry DOI: 10.2210/pdb6t29/pdb
• Descriptor: Calcium/calmodulin-dependent protein kinase type 1D, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 44113.94

Authors

Kraemer, A.,Sorrell, F.,Butterworth, S.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-10-08, release date: 2019-11-13, Last modification date: 2024-01-24)

• Primary citation: Fromont, C.,Atzori, A.,Kaur, D.,Hashmi, L.,Greco, G.,Cabanillas, A.,Nguyen, H.V.,Jones, D.H.,Garzon, M.,Varela, A.,Stevenson, B.,Iacobini, G.P.,Lenoir, M.,Rajesh, S.,Box, C.,Kumar, J.,Grant, P.,Novitskaya, V.,Morgan, J.,Sorrell, F.J.,Redondo, C.,Kramer, A.,Harris, C.J.,Leighton, B.,Vickers, S.P.,Cheetham, S.C.,Kenyon, C.,Grabowska, A.M.,Overduin, M.,Berditchevski, F.,Weston, C.J.,Knapp, S.,Fischer, P.M.,Butterworth, S.; Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesityin VivoMouse Model.; J.Med.Chem., 63:6784-6801, 2020; PubMed: 32433887; DOI: 10.1021/acs.jmedchem.9b01803

Experimental method

X-RAY DIFFRACTION (1.484 Å)