6T29
Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 18 (CS587)
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| AAA | 0000166 | molecular_function | nucleotide binding |
| AAA | 0003824 | molecular_function | catalytic activity |
| AAA | 0004672 | molecular_function | protein kinase activity |
| AAA | 0004674 | molecular_function | protein serine/threonine kinase activity |
| AAA | 0004683 | molecular_function | calcium/calmodulin-dependent protein kinase activity |
| AAA | 0005515 | molecular_function | protein binding |
| AAA | 0005516 | molecular_function | calmodulin binding |
| AAA | 0005524 | molecular_function | ATP binding |
| AAA | 0005634 | cellular_component | nucleus |
| AAA | 0005737 | cellular_component | cytoplasm |
| AAA | 0006468 | biological_process | protein phosphorylation |
| AAA | 0006954 | biological_process | inflammatory response |
| AAA | 0007165 | biological_process | signal transduction |
| AAA | 0007399 | biological_process | nervous system development |
| AAA | 0010975 | biological_process | regulation of neuron projection development |
| AAA | 0010976 | biological_process | positive regulation of neuron projection development |
| AAA | 0016301 | molecular_function | kinase activity |
| AAA | 0016740 | molecular_function | transferase activity |
| AAA | 0032793 | biological_process | positive regulation of CREB transcription factor activity |
| AAA | 0043065 | biological_process | positive regulation of apoptotic process |
| AAA | 0043066 | biological_process | negative regulation of apoptotic process |
| AAA | 0050766 | biological_process | positive regulation of phagocytosis |
| AAA | 0050773 | biological_process | regulation of dendrite development |
| AAA | 0060267 | biological_process | positive regulation of respiratory burst |
| AAA | 0071622 | biological_process | regulation of granulocyte chemotaxis |
| AAA | 0090023 | biological_process | positive regulation of neutrophil chemotaxis |
| AAA | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGAFSEVVlAeekatgklfavkc.....IPKK |
| Chain | Residue | Details |
| AAA | LEU29-LYS57 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNLLY |
| Chain | Residue | Details |
| AAA | ILE140-TYR152 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
