2WEL

Crystal structure of SU6656-bound calcium/calmodulin-dependent protein kinase II delta in complex with calmodulin

Summary for 2WEL

• Entry DOI: 10.2210/pdb2wel/pdb
• Related: 1AJI 1CDL 1CLL 1IWQ 1J7O 1J7P 1K90 1K93 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YRT 1YRU 1ZOT 2BE6 2F3Y 2F3Z 2JL2 2V01 2V02 2VAY 2VN9 2W2C 2W73
• Descriptor: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN, CALMODULIN, (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE, ... (7 entities in total)
• Functional Keywords: cellular differentiation, serine/threonine-protein kinase, phosphoprotein, calmodulin-binding, calmodulin binding, kinase, transferase, atp-binding, nucleotide-binding, vascular smooth muscle, serine-threonine kinase
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side : Q13557
• Total number of polymer chains: 2
• Total formula weight: 55040.24

Authors

Pike, A.C.W.,Rellos, P.,Salah, E.,Burgess-Brown, N.,Keates, T.,Muniz, J.,Sethi, R.,Roos, A.,Filippakopoulos, P.,von Delft, F.,Edwards, A.,Weigelt, J.,Arrowsmith, C.H.,Bountra, C.,Knapp, S. (deposition date: 2009-03-31, release date: 2009-04-14, Last modification date: 2023-12-13)

• Primary citation: Rellos, P.,Pike, A.C.W.,Niesen, F.H.,Salah, E.,Lee, W.H.,von Delft, F.,Knapp, S.; Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.; Plos Biol., 8:426-, 2010; PubMed: 20668654; DOI: 10.1371/JOURNAL.PBIO.1000426

Experimental method

X-RAY DIFFRACTION (1.9 Å)