Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+/Calmodulin Displays a Unique Binding Mode

Summary for 4EHQ
DescriptorCalmodulin, Calcium release-activated calcium channel protein 1, CALCIUM ION, ... (5 entities in total)
Functional Keywordscalmodulin, orai1, calcium dependent inactivation, ef hand, calcium binding, calcium-dependent inactivation, calmodulin binding domain of orai1, none, cytosol, protein binding
Biological sourceRattus norvegicus (brown rat,rat,rats)
Cellular locationCytoplasm, cytoskeleton, spindle: P62161
Cell membrane; Multi-pass membrane protein: Q96D31
Total number of polymer chains2
Total formula weight19619.91
Liu, Y.,Zheng, X.,Mueller, G.A.,Sobhany, M.,DeRose, E.F.,Zhang, Y.,London, R.E.,Birnbaumer, L. (deposition date: 2012-04-03, release date: 2012-11-07, Last modification date: 2013-01-02)
Primary citationBirnbaumer, L.,Derose, E.F.,Liu, Y.,London, R.E.,Mueller, G.A.,Sobhany, M.,Zhang, Y.,Zheng, X.
Crystal structure of calmodulin binding domain of orai1 in complex with ca2+*calmodulin displays a unique binding mode.
J.Biol.Chem., 287:43030-43041, 2012
PubMed: 23109337
DOI: 110.1074/jbc.M112.380964
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-09