6HGO
| Crystal Structure of human IL-17F | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17F, ... | Authors: | Rondeau, J.M, Goepfert, A. | Deposit date: | 2018-08-23 | Release date: | 2019-11-20 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling. Immunity, 52, 2020
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2HSH
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1OW3
| Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho-GTPase-activating protein 1, ... | Authors: | Graham, D.L, Lowe, P.N, Grime, G.W, Marsh, M, Rittinger, K, Smerdon, S.J, Gamblin, S.J, Eccleston, J.F. | Deposit date: | 2003-03-28 | Release date: | 2003-05-06 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | MgF(3)(-) as a Transition State Analog of Phosphoryl Transfer Chem.Biol., 9, 2002
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2HXK
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1Y6K
| Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain | Descriptor: | Interleukin-10, Interleukin-10 receptor alpha chain | Authors: | Yoon, S.I, Jones, B.C, Josepson, K, Logsdon, N.J, Walter, M.R. | Deposit date: | 2004-12-06 | Release date: | 2005-12-20 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. Structure, 13, 2005
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4AEN
| HLA-DR1 with covalently linked CLIP106-120 in reversed orientation | Descriptor: | GLYCEROL, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, ... | Authors: | Schlundt, A, Guenther, S, Sticht, J, Wieczorek, M, Roske, Y, Heinemann, U, Freund, C. | Deposit date: | 2012-01-11 | Release date: | 2012-08-01 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Peptide Linkage to the Alpha-Subunit of Mhcii Creates a Stably Inverted Antigen Presentation Complex. J.Mol.Biol., 423, 2012
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1XCG
| Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF | Descriptor: | Rho guanine nucleotide exchange factor 11, Transforming protein RhoA | Authors: | Derewenda, U, Oleksy, A, Stevenson, A.S, Korczynska, J, Dauter, Z, Somlyo, A.P, Otlewski, J, Somlyo, A.V, Derewenda, Z.S. | Deposit date: | 2004-09-01 | Release date: | 2004-12-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle Structure, 12, 2004
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1E9J
| SOLUTION STRUCTURE OF THE A-SUBUNIT OF HUMAN CHORIONIC GONADOTROPIN [INCLUDING A SINGLE GLCNAC RESIDUE AT ASN52 AND ASN78] | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHORIONIC GONADOTROPIN | Authors: | Erbel, P.J.A, Karimi-Nejad, Y, van Kuik, J.A, Boelens, R, Kamerling, J.P, Vliegenthart, J.F.G. | Deposit date: | 2000-10-18 | Release date: | 2002-07-25 | Last modified: | 2020-07-29 | Method: | SOLUTION NMR | Cite: | Effects of the N-linked glycans on the 3D structure of the free alpha-subunit of human chorionic gonadotropin. Biochemistry, 39, 2000
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2JLD
| Extremely Tight Binding of Ruthenium Complex to Glycogen Synthase Kinase 3 | Descriptor: | GLYCOGEN SYNTHASE KINASE-3 BETA, PEPTIDE (ALA-GLY-GLY-ALA-ALA-ALA-ALA-ALA), RUTHENIUM PYRIDOCARBAZOLE | Authors: | Atilla-Gokcumen, G.E, Pagano, N, Streu, C, Maksimoska, J, Filippakopoulos, P, Knapp, S, Meggers, E. | Deposit date: | 2008-09-08 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Extremely Tight Binding of a Ruthenium Complex to Glycogen Synthase Kinase 3. Chembiochem, 9, 2008
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4ORA
| Crystal structure of a human calcineurin mutant | Descriptor: | CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ... | Authors: | Li, S.J, Wang, J, Wu, J.W, Wang, Z.X. | Deposit date: | 2014-02-11 | Release date: | 2015-05-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.747 Å) | Cite: | Cooperative autoinhibition and multi-level activation mechanisms of calcineurin To be Published
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1PCF
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4ORB
| Crystal structure of mouse calcineurin | Descriptor: | CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ... | Authors: | Ma, L, Li, S.J, Wang, J, Wu, J.W, Wang, Z.X. | Deposit date: | 2014-02-11 | Release date: | 2015-05-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.108 Å) | Cite: | Cooperative autoinhibition and multi-level activation mechanisms of calcineurin To be Published
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4ORC
| Crystal structure of mammalian calcineurin | Descriptor: | CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ... | Authors: | Ma, L, Li, S.J, Wang, J, Wu, J.W, Wang, Z.X. | Deposit date: | 2014-02-11 | Release date: | 2015-05-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Cooperative autoinhibition and multi-level activation mechanisms of calcineurin To be Published
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2N0A
| Atomic-resolution structure of alpha-synuclein fibrils | Descriptor: | Alpha-synuclein | Authors: | Tuttle, M.D, Comellas, G, Nieuwkoop, A.J, Covell, D.J, Berthold, D.A, Kloepper, K.D, Courtney, J.M, Kim, J.K, Schwieters, C.D, Lee, V.M, George, J.M, Rienstra, C.M. | Deposit date: | 2015-03-04 | Release date: | 2016-03-23 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Solid-state NMR structure of a pathogenic fibril of full-length human alpha-synuclein. Nat.Struct.Mol.Biol., 23, 2016
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8T0C
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8T0E
| TRPV1 in Nanodisc not bound with lysophosphatidic acid (apo) | Descriptor: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1 | Authors: | Arnold, W.R, Cheng, Y. | Deposit date: | 2023-05-31 | Release date: | 2024-05-08 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 31, 2024
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8T10
| TRPV1 in nanodisc bound with two LPA molecules in opposite monomers | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-06-01 | Release date: | 2024-05-08 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 31, 2024
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8T0Y
| TRPV1 in nanodisc bound with one LPA in one monomer | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... | Authors: | Arnold, W.R, Cheng, Y. | Deposit date: | 2023-06-01 | Release date: | 2024-05-08 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 31, 2024
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4HPT
| Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying complete phosphoryl transfer of AMP-PNP onto a substrate peptide | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, cAMP-dependent protein kinase catalytic subunit alpha, ... | Authors: | Bastidas, A.C, Steichen, J.M, Wu, J, Taylor, S.S. | Deposit date: | 2012-10-24 | Release date: | 2013-03-20 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Phosphoryl transfer by protein kinase a is captured in a crystal lattice. J.Am.Chem.Soc., 135, 2013
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4HPU
| Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying partial phosphoryl transfer of AMP-PNP onto a substrate peptide | Descriptor: | MAGNESIUM ION, MYRISTIC ACID, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Bastidas, A.C, Steichen, J.M, Wu, J, Taylor, S.S. | Deposit date: | 2012-10-24 | Release date: | 2013-03-20 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Phosphoryl transfer by protein kinase a is captured in a crystal lattice. J.Am.Chem.Soc., 135, 2013
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4QHU
| Crystal Structure of IL-17A/Fab6785 complex | Descriptor: | CHLORIDE ION, Fab6785 heavy chain, Fab6785 light chain, ... | Authors: | Luo, J, Gilliland, G.L, Malia, T, Obmolova, G, Teplyakov, A. | Deposit date: | 2014-05-29 | Release date: | 2015-08-05 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | IL-17A Asymmetry in a Complex with a Neutralizing Antibody Fab6785 Reveals a Potential Mechanism of Receptor Differentiation To be Published
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8Q4L
| GBP1 bound by 14-3-3sigma | Descriptor: | 14-3-3 protein sigma, Guanylate-binding protein 1 | Authors: | Pfleiderer, M.M, Liu, X, Fisch, D, Anastasakou, E, Frickel, E.M, Galej, W.P. | Deposit date: | 2023-08-07 | Release date: | 2023-10-11 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (5.12 Å) | Cite: | PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection. Science, 382, 2023
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4P2P
| AN INDEPENDENT CRYSTALLOGRAPHIC REFINEMENT OF PORCINE PHOSPHOLIPASE A2 AT 2.4 ANGSTROMS RESOLUTION | Descriptor: | CALCIUM ION, PHOSPHOLIPASE A2 | Authors: | Finzel, B.C, Ohlendorf, D.H, Weber, P.C, Salemme, F.R. | Deposit date: | 1991-10-22 | Release date: | 1992-01-15 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | An independent crystallographic refinement of porcine phospholipase A2 at 2.4 A resolution Acta Crystallogr.,Sect.B, 47, 1991
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2E31
| Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase | Descriptor: | F-box only protein 2, S-phase kinase-associated protein 1A | Authors: | Mizushima, T, Yoshida, Y, Kumanomidou, T, Hasegawa, Y, Yamane, T, Tanaka, K. | Deposit date: | 2006-11-20 | Release date: | 2007-03-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for the selection of glycosylated substrates by SCFFbs1 ubiquitin ligase Proc.Natl.Acad.Sci.Usa, 104, 2007
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6C16
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