PDB: 608 resultsInfo pagesStatus searchChemie searchBIRD

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5IQP	14-3-3 PROTEIN TAU ISOFORM Descriptor: 14-3-3 protein theta, SULFATE ION Authors: Xiao, B, Smerdon, S.J, Gamblin, S.J. Deposit date: 2016-03-11 Release date: 2016-03-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.602 Å) Cite: Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways Nature, 376, 1995
5HF3	Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma Descriptor: 14-3-3 protein sigma, modified Tau peptide Authors: Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C. Deposit date: 2016-01-06 Release date: 2016-01-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
5F74	Crystal structure of ChREBP:14-3-3 complex bound with AMP Descriptor: 14-3-3 protein beta/alpha, ADENOSINE MONOPHOSPHATE, Carbohydrate-responsive element-binding protein Authors: Jung, H, Uyeda, K. Deposit date: 2015-12-07 Release date: 2016-03-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR. J.Biol.Chem., 291, 2016
5EXA	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, Fusicoccin A-THF derivative, ... Authors: Bier, D, Ottmann, C. Deposit date: 2015-11-23 Release date: 2016-05-04 Last modified: 2018-12-19 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
5EWZ	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, GRB2-associated-binding protein 2 Authors: Bier, D, Ottmann, C. Deposit date: 2015-11-23 Release date: 2016-05-04 Last modified: 2018-12-19 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
5D3F	Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A Descriptor: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, FUSICOCCIN Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-06 Release date: 2016-03-16 Last modified: 2019-03-13 Method: X-RAY DIFFRACTION (2.74 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
5D3E	Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795 Descriptor: 14-3-3 protein gamma, Cystic fibrosis transmembrane conductance regulator Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-06 Release date: 2016-03-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
5D2D	Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 Descriptor: 14-3-3 protein zeta/delta, CHLORIDE ION, Cystic fibrosis transmembrane conductance regulator, ... Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-05 Release date: 2016-03-16 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
5BY9	The crystal structure of polyglycilated 14-3-3 protein from Giardia intestinalis Descriptor: 14-3-3 protein Authors: Fiorillo, A, Ilari, A, Lalle, M. Deposit date: 2015-06-10 Release date: 2016-04-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (4 Å) Cite: Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
5BTV	Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Ottmann, C, Schumacher, B, Bartel, M. Deposit date: 2015-06-03 Release date: 2016-07-20 Last modified: 2019-03-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. Faseb J., 29, 2015
4ZQ0	crystal structure of Giardia 14-3-3 in complex with the phosphopeptide A8Ap Descriptor: 14-3-3 protein, A8Ap phosphopeptide, PHOSPHATE ION Authors: Fiorillo, A, Ilari, A. Deposit date: 2015-05-08 Release date: 2016-03-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
4ZDR	Crystal structure of 14-3-3[zeta]-LKB1 fusion protein Descriptor: 14-3-3 protein zeta/delta,GGSGGS linker,Serine/threonine-protein kinase STK11, GLYCEROL, PROPANE, ... Authors: Ding, S, Shi, Z.B. Deposit date: 2015-04-18 Release date: 2015-09-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.899 Å) Cite: Structure of the 14-3-3 zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3. Acta Crystallogr.,Sect.F, 71, 2015
4Y5I	Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Microtubule-associated protein tau Authors: Leysen, S, Bartel, M, Milroy, L, Brunsveld, L, Ottmann, C. Deposit date: 2015-02-11 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
4Y3B	Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma Descriptor: (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-THR-[H][C@@]1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCCN1C Authors: Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C. Deposit date: 2015-02-10 Release date: 2015-12-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
4Y32	Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma Descriptor: (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-CNC(C(C)O)C(=O)N1CCCC1CCOC Authors: Bartel, M, Milroy, L, Bier, D, Brunsveld, L, Ottmann, C. Deposit date: 2015-02-10 Release date: 2015-12-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
4WRQ	Crystal Structure of 14-3-3 zeta with Chibby peptide Descriptor: 14-3-3 protein zeta/delta, Chibby Authors: Killoran, R.C, Shilton, B.H, Choy, W.Y. Deposit date: 2014-10-24 Release date: 2015-05-06 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.409 Å) Cite: Structural Analysis of the 14-3-3 zeta /Chibby Interaction Involved in Wnt/ beta-Catenin Signaling. Plos One, 10, 2015
4QLI	A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation Descriptor: 14-3-3 protein sigma, GLYCEROL, MAGNESIUM ION, ... Authors: Bier, D, Ottmann, C. Deposit date: 2014-06-12 Release date: 2015-06-17 Method: X-RAY DIFFRACTION (1.45 Å) Cite: A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation To be Published
4O46	14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228 Descriptor: 14-3-3 protein gamma, Nonstructural protein 1, UNKNOWN ATOM OR ION, ... Authors: Qin, S, Liu, Y, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2013-12-18 Release date: 2014-04-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1. Nat Commun, 5, 2014
4N84	Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S Authors: Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. Deposit date: 2013-10-17 Release date: 2014-02-19 Last modified: 2014-03-12 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
4N7Y	Crystal structure of 14-3-3zeta in complex with a 8-carbon-linker cyclic peptide derived from ExoS Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S Authors: Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. Deposit date: 2013-10-16 Release date: 2014-02-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
4N7G	Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S, HEXAETHYLENE GLYCOL Authors: Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. Deposit date: 2013-10-15 Release date: 2014-02-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
4BG6	14-3-3 interaction with Rnd3 prenyl-phosphorylation motif Descriptor: 14-3-3 PROTEIN ZETA/DELTA, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FARNESYL, ... Authors: Riou, P, Kjaer, S, Purkiss, A, O'Reilly, N, McDonald, N.Q. Deposit date: 2013-03-23 Release date: 2013-05-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: 14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins. Cell(Cambridge,Mass.), 153, 2013
4JDD	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, FUSICOCCIN Authors: Bier, D, Ottmann, C. Deposit date: 2013-02-25 Release date: 2013-05-15 Last modified: 2017-06-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4JC3	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, MAGNESIUM ION Authors: Bier, D, Ottmann, C. Deposit date: 2013-02-21 Release date: 2013-05-15 Last modified: 2017-06-07 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4J6S	14-3-3gamma complexed with the N-terminal sequence of tyrosine hydroxylase (residues 1-43) Descriptor: 14-3-3 protein gamma, N-terminal motif of tyrosine hydroxylase Authors: Mileni, M, Martinez, A, Stevens, R.C. Deposit date: 2013-02-11 Release date: 2013-10-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.08 Å) Cite: The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. J.Mol.Biol., 426, 2014

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