4Y3B

Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma

Summary for 4Y3B

• Entry DOI: 10.2210/pdb4y3b/pdb
• Descriptor: 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-THR-[H][C@@]1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCCN1C, (2S)-2-(2-methoxyethyl)pyrrolidine, ... (4 entities in total)
• Functional Keywords: 14-3-3 fold, tau, all alpha-helical, adapter protein, protein-protein interaction, peptide binding protein, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 54918.75

Authors

Bartel, M.,Milroy, L.G.,Brunsveld, L.,Ottmann, C. (deposition date: 2015-02-10, release date: 2015-12-23, Last modification date: 2024-01-10)

• Primary citation: Milroy, L.G.,Bartel, M.,Henen, M.A.,Leysen, S.,Adriaans, J.M.,Brunsveld, L.,Landrieu, I.,Ottmann, C.; Stabilizer-Guided Inhibition of Protein-Protein Interactions.; Angew.Chem.Int.Ed.Engl., 54:15720-15724, 2015; PubMed: 26537010; DOI: 10.1002/anie.201507976

Experimental method

X-RAY DIFFRACTION (1.8 Å)