5D3E

Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795

Summary for 5D3E

Entry DOI	10.2210/pdb5d3e/pdb
Descriptor	14-3-3 protein gamma, Cystic fibrosis transmembrane conductance regulator (3 entities in total)
Functional Keywords	protein-peptide complex, phosphorylation, tandem binding, signaling protein
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm : P61981 Early endosome membrane ; Multi-pass membrane protein : P13569
Total number of polymer chains	9
Total formula weight	180433.27
Authors	Stevers, L.M.,Leysen, S.F.R.,Ottmann, C. (deposition date: 2015-08-06, release date: 2016-03-16, Last modification date: 2024-01-10)
Primary citation	Stevers, L.M.,Lam, C.V.,Leysen, S.F.,Meijer, F.A.,van Scheppingen, D.S.,de Vries, R.M.,Carlile, G.W.,Milroy, L.G.,Thomas, D.Y.,Brunsveld, L.,Ottmann, C. Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113:E1152-E1161, 2016 Cited by PubMed: 26888287 DOI: 10.1073/pnas.1516631113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation