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5D3E

Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795

Functional Information from GO Data
ChainGOidnamespacecontents
A0002181biological_processcytoplasmic translation
A0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
A0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
A0003723molecular_functionRNA binding
A0005080molecular_functionprotein kinase C binding
A0005159molecular_functioninsulin-like growth factor receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0006469biological_processnegative regulation of protein kinase activity
A0006605biological_processprotein targeting
A0007165biological_processsignal transduction
A0008104biological_processprotein localization
A0008426molecular_functionprotein kinase C inhibitor activity
A0009966biological_processregulation of signal transduction
A0016020cellular_componentmembrane
A0019904molecular_functionprotein domain specific binding
A0022409biological_processpositive regulation of cell-cell adhesion
A0030971molecular_functionreceptor tyrosine kinase binding
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031669biological_processcellular response to nutrient levels
A0031982cellular_componentvesicle
A0032869biological_processcellular response to insulin stimulus
A0032880biological_processregulation of protein localization
A0034198biological_processcellular response to amino acid starvation
A0038202biological_processTORC1 signaling
A0042149biological_processcellular response to glucose starvation
A0042802molecular_functionidentical protein binding
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0045202cellular_componentsynapse
A0045664biological_processregulation of neuron differentiation
A0045947biological_processnegative regulation of translational initiation
A0045948biological_processpositive regulation of translational initiation
A0048167biological_processregulation of synaptic plasticity
A0050821biological_processprotein stabilization
A0050868biological_processnegative regulation of T cell activation
A0050870biological_processpositive regulation of T cell activation
A0061462biological_processprotein localization to lysosome
A0070062cellular_componentextracellular exosome
A0085020biological_processprotein K6-linked ubiquitination
A0098793cellular_componentpresynapse
A0140031molecular_functionphosphorylation-dependent protein binding
A0140311molecular_functionprotein sequestering activity
A1904262biological_processnegative regulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
B0002181biological_processcytoplasmic translation
B0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
B0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
B0003723molecular_functionRNA binding
B0005080molecular_functionprotein kinase C binding
B0005159molecular_functioninsulin-like growth factor receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0005925cellular_componentfocal adhesion
B0006469biological_processnegative regulation of protein kinase activity
B0006605biological_processprotein targeting
B0007165biological_processsignal transduction
B0008104biological_processprotein localization
B0008426molecular_functionprotein kinase C inhibitor activity
B0009966biological_processregulation of signal transduction
B0016020cellular_componentmembrane
B0019904molecular_functionprotein domain specific binding
B0022409biological_processpositive regulation of cell-cell adhesion
B0030971molecular_functionreceptor tyrosine kinase binding
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031669biological_processcellular response to nutrient levels
B0031982cellular_componentvesicle
B0032869biological_processcellular response to insulin stimulus
B0032880biological_processregulation of protein localization
B0034198biological_processcellular response to amino acid starvation
B0038202biological_processTORC1 signaling
B0042149biological_processcellular response to glucose starvation
B0042802molecular_functionidentical protein binding
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045202cellular_componentsynapse
B0045664biological_processregulation of neuron differentiation
B0045947biological_processnegative regulation of translational initiation
B0045948biological_processpositive regulation of translational initiation
B0048167biological_processregulation of synaptic plasticity
B0050821biological_processprotein stabilization
B0050868biological_processnegative regulation of T cell activation
B0050870biological_processpositive regulation of T cell activation
B0061462biological_processprotein localization to lysosome
B0070062cellular_componentextracellular exosome
B0085020biological_processprotein K6-linked ubiquitination
B0098793cellular_componentpresynapse
B0140031molecular_functionphosphorylation-dependent protein binding
B0140311molecular_functionprotein sequestering activity
B1904262biological_processnegative regulation of TORC1 signaling
B1904263biological_processpositive regulation of TORC1 signaling
E0002181biological_processcytoplasmic translation
E0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
E0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
E0003723molecular_functionRNA binding
E0005080molecular_functionprotein kinase C binding
E0005159molecular_functioninsulin-like growth factor receptor binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005759cellular_componentmitochondrial matrix
E0005829cellular_componentcytosol
E0005925cellular_componentfocal adhesion
E0006469biological_processnegative regulation of protein kinase activity
E0006605biological_processprotein targeting
E0007165biological_processsignal transduction
E0008104biological_processprotein localization
E0008426molecular_functionprotein kinase C inhibitor activity
E0009966biological_processregulation of signal transduction
E0016020cellular_componentmembrane
E0019904molecular_functionprotein domain specific binding
E0022409biological_processpositive regulation of cell-cell adhesion
E0030971molecular_functionreceptor tyrosine kinase binding
E0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E0031669biological_processcellular response to nutrient levels
E0031982cellular_componentvesicle
E0032869biological_processcellular response to insulin stimulus
E0032880biological_processregulation of protein localization
E0034198biological_processcellular response to amino acid starvation
E0038202biological_processTORC1 signaling
E0042149biological_processcellular response to glucose starvation
E0042802molecular_functionidentical protein binding
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0045202cellular_componentsynapse
E0045664biological_processregulation of neuron differentiation
E0045947biological_processnegative regulation of translational initiation
E0045948biological_processpositive regulation of translational initiation
E0048167biological_processregulation of synaptic plasticity
E0050821biological_processprotein stabilization
E0050868biological_processnegative regulation of T cell activation
E0050870biological_processpositive regulation of T cell activation
E0061462biological_processprotein localization to lysosome
E0070062cellular_componentextracellular exosome
E0085020biological_processprotein K6-linked ubiquitination
E0098793cellular_componentpresynapse
E0140031molecular_functionphosphorylation-dependent protein binding
E0140311molecular_functionprotein sequestering activity
E1904262biological_processnegative regulation of TORC1 signaling
E1904263biological_processpositive regulation of TORC1 signaling
F0002181biological_processcytoplasmic translation
F0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
F0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
F0003723molecular_functionRNA binding
F0005080molecular_functionprotein kinase C binding
F0005159molecular_functioninsulin-like growth factor receptor binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005759cellular_componentmitochondrial matrix
F0005829cellular_componentcytosol
F0005925cellular_componentfocal adhesion
F0006469biological_processnegative regulation of protein kinase activity
F0006605biological_processprotein targeting
F0007165biological_processsignal transduction
F0008104biological_processprotein localization
F0008426molecular_functionprotein kinase C inhibitor activity
F0009966biological_processregulation of signal transduction
F0016020cellular_componentmembrane
F0019904molecular_functionprotein domain specific binding
F0022409biological_processpositive regulation of cell-cell adhesion
F0030971molecular_functionreceptor tyrosine kinase binding
F0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
F0031669biological_processcellular response to nutrient levels
F0031982cellular_componentvesicle
F0032869biological_processcellular response to insulin stimulus
F0032880biological_processregulation of protein localization
F0034198biological_processcellular response to amino acid starvation
F0038202biological_processTORC1 signaling
F0042149biological_processcellular response to glucose starvation
F0042802molecular_functionidentical protein binding
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0045202cellular_componentsynapse
F0045664biological_processregulation of neuron differentiation
F0045947biological_processnegative regulation of translational initiation
F0045948biological_processpositive regulation of translational initiation
F0048167biological_processregulation of synaptic plasticity
F0050821biological_processprotein stabilization
F0050868biological_processnegative regulation of T cell activation
F0050870biological_processpositive regulation of T cell activation
F0061462biological_processprotein localization to lysosome
F0070062cellular_componentextracellular exosome
F0085020biological_processprotein K6-linked ubiquitination
F0098793cellular_componentpresynapse
F0140031molecular_functionphosphorylation-dependent protein binding
F0140311molecular_functionprotein sequestering activity
F1904262biological_processnegative regulation of TORC1 signaling
F1904263biological_processpositive regulation of TORC1 signaling
I0002181biological_processcytoplasmic translation
I0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
I0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
I0003723molecular_functionRNA binding
I0005080molecular_functionprotein kinase C binding
I0005159molecular_functioninsulin-like growth factor receptor binding
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005759cellular_componentmitochondrial matrix
I0005829cellular_componentcytosol
I0005925cellular_componentfocal adhesion
I0006469biological_processnegative regulation of protein kinase activity
I0006605biological_processprotein targeting
I0007165biological_processsignal transduction
I0008104biological_processprotein localization
I0008426molecular_functionprotein kinase C inhibitor activity
I0009966biological_processregulation of signal transduction
I0016020cellular_componentmembrane
I0019904molecular_functionprotein domain specific binding
I0022409biological_processpositive regulation of cell-cell adhesion
I0030971molecular_functionreceptor tyrosine kinase binding
I0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
I0031669biological_processcellular response to nutrient levels
I0031982cellular_componentvesicle
I0032869biological_processcellular response to insulin stimulus
I0032880biological_processregulation of protein localization
I0034198biological_processcellular response to amino acid starvation
I0038202biological_processTORC1 signaling
I0042149biological_processcellular response to glucose starvation
I0042802molecular_functionidentical protein binding
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0045202cellular_componentsynapse
I0045664biological_processregulation of neuron differentiation
I0045947biological_processnegative regulation of translational initiation
I0045948biological_processpositive regulation of translational initiation
I0048167biological_processregulation of synaptic plasticity
I0050821biological_processprotein stabilization
I0050868biological_processnegative regulation of T cell activation
I0050870biological_processpositive regulation of T cell activation
I0061462biological_processprotein localization to lysosome
I0070062cellular_componentextracellular exosome
I0085020biological_processprotein K6-linked ubiquitination
I0098793cellular_componentpresynapse
I0140031molecular_functionphosphorylation-dependent protein binding
I0140311molecular_functionprotein sequestering activity
I1904262biological_processnegative regulation of TORC1 signaling
I1904263biological_processpositive regulation of TORC1 signaling
J0002181biological_processcytoplasmic translation
J0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
J0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
J0003723molecular_functionRNA binding
J0005080molecular_functionprotein kinase C binding
J0005159molecular_functioninsulin-like growth factor receptor binding
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005759cellular_componentmitochondrial matrix
J0005829cellular_componentcytosol
J0005925cellular_componentfocal adhesion
J0006469biological_processnegative regulation of protein kinase activity
J0006605biological_processprotein targeting
J0007165biological_processsignal transduction
J0008104biological_processprotein localization
J0008426molecular_functionprotein kinase C inhibitor activity
J0009966biological_processregulation of signal transduction
J0016020cellular_componentmembrane
J0019904molecular_functionprotein domain specific binding
J0022409biological_processpositive regulation of cell-cell adhesion
J0030971molecular_functionreceptor tyrosine kinase binding
J0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
J0031669biological_processcellular response to nutrient levels
J0031982cellular_componentvesicle
J0032869biological_processcellular response to insulin stimulus
J0032880biological_processregulation of protein localization
J0034198biological_processcellular response to amino acid starvation
J0038202biological_processTORC1 signaling
J0042149biological_processcellular response to glucose starvation
J0042802molecular_functionidentical protein binding
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0045202cellular_componentsynapse
J0045664biological_processregulation of neuron differentiation
J0045947biological_processnegative regulation of translational initiation
J0045948biological_processpositive regulation of translational initiation
J0048167biological_processregulation of synaptic plasticity
J0050821biological_processprotein stabilization
J0050868biological_processnegative regulation of T cell activation
J0050870biological_processpositive regulation of T cell activation
J0061462biological_processprotein localization to lysosome
J0070062cellular_componentextracellular exosome
J0085020biological_processprotein K6-linked ubiquitination
J0098793cellular_componentpresynapse
J0140031molecular_functionphosphorylation-dependent protein binding
J0140311molecular_functionprotein sequestering activity
J1904262biological_processnegative regulation of TORC1 signaling
J1904263biological_processpositive regulation of TORC1 signaling
Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG42-VAL52

site_idPS00797
Number of Residues20
Details1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
ChainResidueDetails
ATYR216-SER235

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:1377674, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:9385646
ChainResidueDetails
CSEP768
IARG132
JARG57
JARG132
GSEP768
KSEP768
BARG132
EARG57
EARG132
FARG57
FARG132
IARG57

site_idSWS_FT_FI2
Number of Residues3
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:1377674
ChainResidueDetails
CSER790
GSER790
KSER790
FMET1
IMET1
JMET1

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:1377674, ECO:0000269|PubMed:22119790, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:9385646
ChainResidueDetails
CSEP795
GSEP795
KSEP795
FVAL2
IVAL2
JVAL2

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER71
BSER71
ESER71
FSER71
ISER71
JSER71

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P61983
ChainResidueDetails
ATYR133
BTYR133
ETYR133
FTYR133
ITYR133
JTYR133

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0000269|Ref.7
ChainResidueDetails
ATHR145
BTHR145
ETHR145
FTHR145
ITHR145
JTHR145

site_idSWS_FT_FI7
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P61983
ChainResidueDetails
ASER215
BSER215
ESER215
FSER215
ISER215
JSER215

site_idSWS_FT_FI8
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR234
BTHR234
ETHR234
FTHR234
ITHR234
JTHR234

site_idSWS_FT_FI9
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER235
BSER235
ESER235
FSER235
ISER235
JSER235

237735

PDB entries from 2025-06-18

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