4Y5I

Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma

Summary for 4Y5I

• Entry DOI: 10.2210/pdb4y5i/pdb
• Related: 4Y32 4Y3B 4Y3V
• Descriptor: 14-3-3 protein sigma, Microtubule-associated protein tau, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: 14-3-3 sigma, protein-protein interaction, inhibitor, tau, peptide-hybrid, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 55046.80

Authors

Leysen, S.,Bartel, M.,Milroy, L.,Brunsveld, L.,Ottmann, C. (deposition date: 2015-02-11, release date: 2016-01-13, Last modification date: 2024-01-10)

• Primary citation: Milroy, L.G.,Bartel, M.,Henen, M.A.,Leysen, S.,Adriaans, J.M.,Brunsveld, L.,Landrieu, I.,Ottmann, C.; Stabilizer-Guided Inhibition of Protein-Protein Interactions.; Angew.Chem.Int.Ed.Engl., 54:15720-15724, 2015; PubMed: 26537010; DOI: 10.1002/anie.201507976

Experimental method

X-RAY DIFFRACTION (1.4 Å)