4ZDR

Crystal structure of 14-3-3[zeta]-LKB1 fusion protein

Summary for 4ZDR

• Entry DOI: 10.2210/pdb4zdr/pdb
• Descriptor: 14-3-3 protein zeta/delta,GGSGGS linker,Serine/threonine-protein kinase STK11, GLYCEROL, SULFATE ION, ... (5 entities in total)
• Functional Keywords: chimeric protein, regulatory protein, tumor suppressor, serine/threonine-protein kinase, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 61431.52

Authors

Ding, S.,Shi, Z.B. (deposition date: 2015-04-18, release date: 2015-09-09, Last modification date: 2023-11-08)

Primary citation

Ding, S.,Zhou, R.,Zhu, Y.
Structure of the 14-3-3 zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3.
Acta Crystallogr.,Sect.F, 71:1114-1119, 2015

PubMed Abstract: The 14-3-3 proteins are a family of highly conserved proteins that play key roles in many cellular processes. The tumour suppressor LKB1 regulates cell polarity, cell growth and energy metabolism. 14-3-3 proteins bind to LKB1 and suppress its functions. Previously, preliminary crystallographic data for the 14-3-3ζ-LKB1 fusion protein have been reported. Here, the crystal structure of this fusion protein was solved and a novel potential binding mode of 14-3-3 to its ligands was found.

PubMed: 26323294
DOI: 10.1107/S2053230X15012595

Experimental method

X-RAY DIFFRACTION (2.899 Å)