8HDO
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![BU of 8hdo by Molmil](/molmil-images/mine/8hdo) | Structure of A2BR bound to synthetic agonists BAY 60-6583 | Descriptor: | 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide, Adenosine A2b receptor, CHOLESTEROL, ... | Authors: | Cai, H, Xu, Y, Xu, H.E, Jiang, Y. | Deposit date: | 2022-11-05 | Release date: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Structures of adenosine receptor A 2B R bound to endogenous and synthetic agonists. Cell Discov, 8, 2022
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8HDP
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![BU of 8hdp by Molmil](/molmil-images/mine/8hdp) | Structure of A2BR bound to endogenous agonists adenosine | Descriptor: | ADENOSINE, Adenosine A2b receptor, CHOLESTEROL, ... | Authors: | Cai, H, Xu, Y, Xu, H.E, Jiang, Y. | Deposit date: | 2022-11-05 | Release date: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of adenosine receptor A 2B R bound to endogenous and synthetic agonists. Cell Discov, 8, 2022
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8HDD
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![BU of 8hdd by Molmil](/molmil-images/mine/8hdd) | Complex structure of catalytic, small, and a partial electron transfer subunits from Burkholderia cepacia FAD glucose dehydrogenase | Descriptor: | FE3-S4 CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, Glucose dehydrogenase, ... | Authors: | Yoshida, H, Sode, K. | Deposit date: | 2022-11-04 | Release date: | 2022-12-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Microgravity environment grown crystal structure information based engineering of direct electron transfer type glucose dehydrogenase. Commun Biol, 5, 2022
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8F19
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![BU of 8f19 by Molmil](/molmil-images/mine/8f19) | Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) | Descriptor: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin subunit beta-5, ... | Authors: | Jiou, J, Chook, Y.M. | Deposit date: | 2022-11-04 | Release date: | 2023-07-26 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
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8F1E
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![BU of 8f1e by Molmil](/molmil-images/mine/8f1e) | Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) and H2A-H2B | Descriptor: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Histone H2A.2, ... | Authors: | Jiou, J, Chook, Y.M. | Deposit date: | 2022-11-04 | Release date: | 2023-07-26 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
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8F1A
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![BU of 8f1a by Molmil](/molmil-images/mine/8f1a) | Apo KIF20A[1-565] class-1 in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF20A, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Crozet, V, Ranaivoson, F.M, Houdusse, A, Sosa, H. | Deposit date: | 2022-11-04 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6. Open Biology, 13, 2023
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8F18
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![BU of 8f18 by Molmil](/molmil-images/mine/8f18) | Apo KIF20A[1-565] class-2 in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF20A, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Crozet, V, Ranaivoson, F.M, Houdusse, A, Sosa, H. | Deposit date: | 2022-11-04 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6. Open Biology, 13, 2023
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8HDK
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![BU of 8hdk by Molmil](/molmil-images/mine/8hdk) | Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine and glutamate (minor class in symmetry) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | Authors: | Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S. | Deposit date: | 2022-11-04 | Release date: | 2023-03-29 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
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8BJF
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![BU of 8bjf by Molmil](/molmil-images/mine/8bjf) | Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (inward-facing conformation) | Descriptor: | ATP-binding cassette sub-family C member 4, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE | Authors: | Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. | Deposit date: | 2022-11-04 | Release date: | 2023-08-30 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4. Structure, 31, 2023
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8BJH
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![BU of 8bjh by Molmil](/molmil-images/mine/8bjh) | chimera of the inactive ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, with the double mutation K3528M and K3535I, fused to a proline-Rich-Domain (PRD) and profilin, bound to Latrunculin B-ADP-Mg-actin | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Actin, ... | Authors: | Teixeira-Nunes, M, Renault, L, Retailleau, P. | Deposit date: | 2022-11-04 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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8BJI
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![BU of 8bji by Molmil](/molmil-images/mine/8bji) | chimera of ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo fused to a proline-Rich-Domain (PRD) and profilin, bound to ADP-Mg-actin and a sulfate ion | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Actin, ... | Authors: | Teixeira-Nunes, M, Renault, L, Retailleau, P. | Deposit date: | 2022-11-04 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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8BJJ
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![BU of 8bjj by Molmil](/molmil-images/mine/8bjj) | ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to ATP-Mg-actin, human profilin 1 and a sulfate ion | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Teixeira-Nunes, M, Renault, L, Retailleau, P. | Deposit date: | 2022-11-04 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.699 Å) | Cite: | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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8F0M
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![BU of 8f0m by Molmil](/molmil-images/mine/8f0m) | Monobody 12D5 bound to KRAS(G12D) | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | Authors: | Hattori, T, Glasser, E, Akkapeddi, P, Ketavarapu, G, Teng, K.W, Koide, A, Koide, S. | Deposit date: | 2022-11-03 | Release date: | 2023-07-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors. Proc.Natl.Acad.Sci.USA, 120, 2023
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8F0K
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![BU of 8f0k by Molmil](/molmil-images/mine/8f0k) | Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 | Descriptor: | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Cao, J, Sexton, P.M, Wootten, D.L. | Deposit date: | 2022-11-03 | Release date: | 2023-08-02 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (1.9 Å) | Cite: | Structural insight into selectivity of amylin and calcitonin receptor agonists. Nat.Chem.Biol., 20, 2024
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8F0J
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![BU of 8f0j by Molmil](/molmil-images/mine/8f0j) | Calcitonin Receptor in complex with Gs and Pramlintide analogue peptide San45 | Descriptor: | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J. | Deposit date: | 2022-11-03 | Release date: | 2023-08-02 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (2 Å) | Cite: | Structural insight into selectivity of amylin and calcitonin receptor agonists. Nat.Chem.Biol., 20, 2024
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8HCX
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![BU of 8hcx by Molmil](/molmil-images/mine/8hcx) | Cryo-EM structure of Endothelin1-bound ETBR-Gq complex | Descriptor: | Endothelin receptor type B,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Yuan, Q, Jiang, Y, Xu, H.E, Ji, Y, Duan, J. | Deposit date: | 2022-11-03 | Release date: | 2023-03-22 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of peptide recognition and activation of endothelin receptors. Nat Commun, 14, 2023
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8F0O
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![BU of 8f0o by Molmil](/molmil-images/mine/8f0o) | |
8HD0
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![BU of 8hd0 by Molmil](/molmil-images/mine/8hd0) | Cell divisome sPG hydrolysis machinery FtsEX-EnvC | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ... | Authors: | Zhang, Z, Chen, Y. | Deposit date: | 2022-11-03 | Release date: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Structural insight into the septal peptidoglycan hydrolysis machinery of bacterial cell division To Be Published
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8HD8
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![BU of 8hd8 by Molmil](/molmil-images/mine/8hd8) | Crystal structure of TMPRSS2 in complex with 212-148 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-carbamimidamidobenzoic acid, CALCIUM ION, ... | Authors: | Wang, H, Liu, X, Sun, L, Yang, H. | Deposit date: | 2022-11-03 | Release date: | 2023-12-13 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun, 14, 2023
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8BJ7
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![BU of 8bj7 by Molmil](/molmil-images/mine/8bj7) | |
8BJ8
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![BU of 8bj8 by Molmil](/molmil-images/mine/8bj8) | |
8F0F
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![BU of 8f0f by Molmil](/molmil-images/mine/8f0f) | HIV-1 wild type protease with GRL-110-19A, a chloroacetamide derivative based on Darunavir as P2' group | Descriptor: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[4-(2-chloroacetamido)benzene-1-sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate, CHLORIDE ION, GLYCEROL, ... | Authors: | Wang, Y.-F, Agniswamy, J, Ghosh, A.K, Weber, I.T. | Deposit date: | 2022-11-02 | Release date: | 2023-02-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies. Bioorg.Med.Chem.Lett., 83, 2023
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8F0B
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![BU of 8f0b by Molmil](/molmil-images/mine/8f0b) | Lysozyme Anomalous Dataset at 240 K and 7.1 keV | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Lysozyme C, ... | Authors: | Doukov, T, Yabukarski, F, Herschlag, D. | Deposit date: | 2022-11-02 | Release date: | 2023-03-15 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Obtaining anomalous and ensemble information from protein crystals from 220 K up to physiological temperatures. Acta Crystallogr D Struct Biol, 79, 2023
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8BIK
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![BU of 8bik by Molmil](/molmil-images/mine/8bik) | Crystal structure of human AMPK heterotrimer in complex with allosteric activator C455 | Descriptor: | (3~{R},3~{a}~{R},6~{R},6~{a}~{R})-6-[[6-chloranyl-5-[4-[4-[[dimethyl(oxidanyl)-$l^{4}-sulfanyl]amino]phenyl]phenyl]-3~{H}-imidazo[4,5-b]pyridin-2-yl]oxy]-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]furan-3-ol, 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, ... | Authors: | Schimpl, M, Mather, K.M, Boland, M.L, Rivers, E.L, Srivastava, A, Hemsley, P, Robinson, J, Wan, P.T, Hansen, J, Read, J.A, Trevaskis, J.L, Smith, D.M. | Deposit date: | 2022-11-02 | Release date: | 2024-05-15 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Direct beta 1/ beta 2 AMPK activation reduces liver steatosis but not fibrosis in a mouse model of non-alcoholic steatohepatitis Biorxiv, 2024
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8HCQ
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![BU of 8hcq by Molmil](/molmil-images/mine/8hcq) | Cryo-EM structure of endothelin1-bound ETAR-Gq complex | Descriptor: | Endothelin-1, Endothelin-1 receptor,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Yuan, Q, Jiang, Y, Xu, H.E, Ji, Y, Duan, J. | Deposit date: | 2022-11-02 | Release date: | 2023-03-22 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural basis of peptide recognition and activation of endothelin receptors. Nat Commun, 14, 2023
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