8HD8

Crystal structure of TMPRSS2 in complex with 212-148

Summary for 8HD8

• Entry DOI: 10.2210/pdb8hd8/pdb
• Descriptor: Transmembrane protease serine 2 catalytic chain, CALCIUM ION, 4-carbamimidamidobenzoic acid, ... (6 entities in total)
• Functional Keywords: inhibitor, complex, host, antiviral, antiviral protein, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 88482.52

Authors

Wang, H.,Liu, X.,Sun, L.,Yang, H. (deposition date: 2022-11-03, release date: 2023-12-13, Last modification date: 2024-06-19)

• Primary citation: Wang, H.,Yang, Q.,Liu, X.,Xu, Z.,Shao, M.,Li, D.,Duan, Y.,Tang, J.,Yu, X.,Zhang, Y.,Hao, A.,Wang, Y.,Chen, J.,Zhu, C.,Guddat, L.,Chen, H.,Zhang, L.,Chen, X.,Jiang, B.,Sun, L.,Rao, Z.,Yang, H.; Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry.; Nat Commun, 14:7574-7574, 2023; PubMed: 37990007; DOI: 10.1038/s41467-023-42527-5

Experimental method

X-RAY DIFFRACTION (2.4 Å)