8F0M

Monobody 12D5 bound to KRAS(G12D)

Summary for 8F0M

• Entry DOI: 10.2210/pdb8f0m/pdb
• Related: 8EZG
• Descriptor: Isoform 2B of GTPase KRas, Monobody 12D5, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: signaling protein-de novo protein complex, signaling protein/de novo protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 60917.83

Authors

Hattori, T.,Glasser, E.,Akkapeddi, P.,Ketavarapu, G.,Teng, K.W.,Koide, A.,Koide, S. (deposition date: 2022-11-03, release date: 2023-07-19, Last modification date: 2023-10-25)

• Primary citation: Akkapeddi, P.,Hattori, T.,Khan, I.,Glasser, E.,Koide, A.,Ketavarapu, G.,Whaby, M.,Zuberi, M.,Teng, K.W.,Lefler, J.,Maso, L.,Bang, I.,Ostrowski, M.C.,O'Bryan, J.P.,Koide, S.; Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.; Proc.Natl.Acad.Sci.USA, 120:e2302485120-e2302485120, 2023; PubMed: 37399416; DOI: 10.1073/pnas.2302485120

Experimental method

X-RAY DIFFRACTION (2.44 Å)