8F0M
Monobody 12D5 bound to KRAS(G12D)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Isoform 2B of GTPase KRas | polymer | 171 | 19451.8 | 2 | UniProt (P01116-2) Pfam (PF00071) UniProt (by SIFTS) (P01116) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B, D (B, D) | Monobody 12D5 | polymer | 97 | 10311.4 | 2 | Homo sapiens (Human) | ||
| 3 | E, I (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | F (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 5 | G, H (A, B) | alpha-D-glucopyranose | non-polymer | 180.2 | 2 | Chemie (GLC) | |||
| 6 | J (C) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) | |||
| 7 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 102 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 169 (UniProt: P01116-2)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asp 12 | Gly 12 | engineered mutation |
| Ser 51 | Cys 51 | engineered mutation |
| Leu 80 | Cys 80 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 59526.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1391.4 | |
| All* | Total formula weight | 60917.8 |
