8BIK

Crystal structure of human AMPK heterotrimer in complex with allosteric activator C455

Summary for 8BIK

Entry DOI	10.2210/pdb8bik/pdb
Descriptor	5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (7 entities in total)
Functional Keywords	ampk activator, allosteric activator, adam site, structure-based drug design, selectivity, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	266753.78
Authors	Schimpl, M.,Mather, K.M.,Boland, M.L.,Rivers, E.L.,Srivastava, A.,Hemsley, P.,Robinson, J.,Wan, P.T.,Hansen, J.,Read, J.A.,Trevaskis, J.L.,Smith, D.M. (deposition date: 2022-11-02, release date: 2024-05-15, Last modification date: 2024-06-12)
Primary citation	Mather, K.M.,Boland, M.L.,Rivers, E.L.,Srivastava, A.,Schimpl, M.,Hemsley, P.,Robinson, J.,Wan, P.,Hansen, J.,Read, J.A.,Trevaskis, J.L.,Smith, D.M. Direct beta 1/ beta 2 AMPK activation reduces liver steatosis but not fibrosis in a mouse model of non-alcoholic steatohepatitis Biorxiv, 2024 Cited by DOI: 10.1101/2024.05.30.596624 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation